2023年2月1日 · By mimicking NADH oxidase (NOX) and Cytochrome c oxidase (CcO), the nanozyme can catalyze the cascade reactions on mitochondrial respiratory chain and produce NAD+ without any external stimuli. At both Caenorhabditis elegans (C. elegans) and cell levels, we verified that nanozyme treatment could boost the mitochondrial function and abundance.

2020年10月27日 · Herein, we synthesized a Fe–N doped graphene (FeNGR) nanomaterial that could mimic the activity of NOX by efficiently catalyzing the conversion of NADPH into NADP+ and triggering the generation of oxygen radicals.

2022年12月12日 · Here, we report nitrogen-doped carbon materials templated from g -C 3 N 4 with NOX-like behaviors. The model s-NC nanozyme displays excellent catalytic activity in a wide pH range of 5.0–10.0 and a remarkable specific activity of up to 3.2 U/mg, which is superior to those of the reported NOX mimics.

2021年10月11日 · In this work, by studying the catalytic functions of natural NADH oxidase (NOX), we devised and synthesized a porous carbon-supported cobalt catalyst (Co/C) to mimic NOX. The Co/C can catalyze dehydrogenation of NADH and transfers electrons to …

2021年10月11日 · In this work, by studying the catalytic functions of natural NADH oxidase (NOX), we devised and synthesized a porous carbon-supported cobalt catalyst (Co/C) to mimic NOX. The Co/C can catalyze dehydrogenation of NADH and transfers electrons to …

2020年10月27日 · Herein, we synthesized a Fe–N doped graphene (FeNGR) nanomaterial that could mimic the activity of NOX by efficiently catalyzing the conversion of NADPH into NADP + and triggering the generation of oxygen radicals.

This study introduces a transformative colorimetric detection strategy for NQO1, harnessing an innovative competitive substrate mechanism between NQO1 and a new NADH oxidase (NOX) mimic, cobalt–nitrogen-doped carbon nanozyme (CoNC).

2024年2月1日 · Constructing robust enzyme mimics capable of disrupting cellular nicotinamide adenine dinucleotide (NAD) homeostasis, such as NADH oxidase (NOX) nanozymes, is emerging as a novel and powerful means to treat cancer.

2021年10月8日 · In this work, by studying the catalytic functions of natural NADH oxidase (NOX), we devised and synthesized a porous carbon-supported cobalt catalyst (Co/C) to mimic NOX. The Co/C can catalyze dehydrogenation of NADH and transfers electrons to O2 to produce H2O2.

2020年11月18日 · Herein, we synthesized a Fe-N doped graphene (FeNGR) nanomaterial that could mimic the activity of NOX by efficiently catalyzing the conversion of NADPH into NADP + and triggering the generation of oxygen radicals.