2024年5月2日 · The temporal dynamics of BMPC precursor generation have been inferred based on the emergence of antigen-specific PCs in the BM, in the context of 4-hydroxy-3-nitrophenyl acetyl (NP)-specific B...

SARS-CoV-2 specific antibody-secreting plasma cells (PC) mediating specific humoral immunity have been identified in the human bone marrow (BM) after COVID-19 or vaccination against SARS-CoV-2. However, it remained unclear whether or not they acquire phenotypes of human memory plasma cells.

2017年6月26日 · To detect NP-binding cells in GC or memory B cell population, NP 38 - or NP 44-PE or biotinylated NIP 15-BSA (Biosearch Technologies) were used. To detect surface IL-9R expression, cells were...

2021年5月1日 · In this study, we demonstrate that the bone morphogenetic protein receptor 1A (BMPR1A) signaling pathway, which regulates differentiation and self-renewal in multiple stem cell populations, regulates GC dynamics and resultant establishment of BMPC and MBC.

2024年8月13日 · Expression of the transcriptional regulator ZFP318 is induced in germinal center (GC)-exiting memory B cell precursors and memory B cells (MBCs). Using a conditional ZFP318 fluorescence reporter that also enables ablation of ZFP318-expressing cells, we found that ZFP318-expressing MBCs were highly enriched with GC-derived cells.

Affinity-matured plasma cells (PCs) of varying lifespans are generated through a germinal center (GC) response. The developmental dynamics and genomic programs of antigen-specific PC precursors...

Thus, to discern the potential effect of EFNB1 after NP-KLH immunization, we first derived the CD45.2 competitive competency for the GC/SPPC/BMPC compartment, calculated as the CD45.2 percentage in the GC/SPPC/BMPC compartment normalized to the CD45.2 percentage in the non-GC naïve B cell compartment . This normalization controlled for ...

The temporal dynamics of BMPC precursor generation have been inferred based on the emergence of antigen-specific PCs in the BM, in the context of 4-hydroxy-3-nitrophenyl acetyl (NP)-specific B...

Memory B cells (MBCs) underlie long-lived humoral immunity and are key to the efficacy of prime-boost vaccines. Wang et al. find that MBCs differ in their recall ability and that expression of the transcription regulator ZFP318, which regulates expression of mitochondrial genes, defines MBCs with high recall ability.

2021年5月1日 · In this study, we demonstrate that the bone morphogenetic protein receptor 1A (BMPR1A) signaling pathway, which regulates differentiation and self-renewal in multiple stem cell populations, regulates GC dynamics and resultant establishment of BMPC and MBC.