NPAS2 is a PAS domain -containing protein, which binds other proteins via their own protein-protein (PAS) binding domains.

Dec 25, 2024 · NPAS2 (Neuronal PAS Domain Protein 2) is a Protein Coding gene. Diseases associated with NPAS2 include Seasonal Affective Disorder and Anxiety. Among its related pathways are Circadian Clock and Cellular responses to stimuli.

Oct 12, 2021 · NPAS2, a circadian rhythm gene encoding the neuronal PAS domain protein 2 (NPAS2), has received widespread attention because of its complex functions in cells and diverse roles in disease progression, especially tumorigenesis. NPAS2 binds with DNA at E-box sequences and forms heterodimers with anoth …

Aug 20, 2021 · NPAS2, a circadian rhythm gene encoding the neuronal PAS domain protein 2 (NPAS2), has received widespread attention because of its complex functions in cells and diverse roles in disease progression, especially tumorigenesis. NPAS2 binds with DNA at E-box sequences and forms heterodimers with another circadian protein, brain and muscle ARNT ...

Jul 6, 2001 · Neuronal PAS domain protein 2 (NPAS2) is a transcription factor expressed primarily in the mammalian forebrain. NPAS2 is highly related in primary amino acid sequence to Clock, a transcription factor expressed in the suprachiasmatic nucleus that heterodimerizes with BMAL1 and regulates circadian rhythm.

NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer. Variants in NPAS2 have been associated with seasonality and seasonal affective disorder, phenotypes that …

3 days ago · Npas2 is a circadian gene identified in the mammalian forebrain, where it functions as part of the molecular clock 1.Circadian rhythms are highly conserved biological oscillations with a period of ...

Nov 21, 2002 · Neuronal PAS domain protein 2 (NPAS2) is a mammalian transcription factor that binds DNA as an obligate dimeric partner of BMAL1 and is implicated in the regulation of circadian rhythm. Here we show that both PAS domains of NPAS2 bind heme as a prosthetic group and that the heme status controls DNA binding in vitro.

Dec 1, 2022 · We aimed to investigate the potential role of NPAS2 in controlling diurnal expression and activity of hepatic CYP1A2 and to determine the underlying mechanisms.

Oct 22, 2023 · NPAS2, short for Neuronal PAS Domain Protein 2, is a transcription factor involved in regulating the circadian rhythms and sleep–wake cycles in mammals, including humans. It is a key component of the molecular clockwork that governs daily biological processes.