A time-dependent release of endogenous free DHA followed by NPD1 formation occurs, suggesting that a phospholipase A2 releases the mediator's precursor. When NPD1 is infused during ischemia-reperfusion or added to RPE cells during oxidative stress, apoptotic DNA damage is down-regulated.

Protectin D1 also known as neuroprotectin D1 (when it acts in the nervous system) and abbreviated most commonly as PD1 or NPD1 is a member of the class of specialized proresolving mediators. Like other members of this class of polyunsaturated fatty acid metabolites, it possesses strong anti-inflammatory, anti-apoptotic and neuroprotective activity.

我们前期研究表明,抗炎促修复脂质小分子（PRLMs）参与调控急慢性疼痛；而神经保护素D1（NPD1）是一种新型PRLM，具有强大的神经保护作用，但其受体未知，在化疗诱发神经病理性疼痛中的作用也未见报道。 我们筛选了NPD1的受体，并围绕NPD1及其受体在炎性疼痛和化疗诱发神经病理性疼痛中的作用进行了研究。 结果发现：（1）PRLMs大多通过激活特异的G蛋白偶联受体（GPCR）产生抗炎促修复作用；我们利用GPCR功能测定筛选系统，发现孤儿GPCR …

神经保护素D1(neuroprotectin D1，NPD1)是一种由视网膜色素上皮细胞合成产生的介质，来源于二十二碳六烯酸(docosahexaenoic acid，DHA)的氧化反应，能够抑制细胞因子诱导的促炎因子环氧合酶2(cyclooxygenase-2，COX-2)的表达。

Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1 It has a role as an anti-inflammatory agent, a neuroprotective agent, a PPARgamma agonist, an apoptosis inhibitor, a hepatoprotective agent, a human xenobiotic metabolite and a specialised pro-resolving mediator.

2006年4月5日 · In oxidative stress‐challenged human RPE cells and rat brain undergoing ischemia‐reperfusion, 10,17S‐docosatriene (neuroprotectin D1, NPD1) synthesis evolves. In addition, calcium ionophore A23187, IL‐1β, or the supply of DHA enhances NPD1 synthesis.

2011年1月5日 · Neuroprotectin D1 (NPD1) is a stereoselective mediator derived from the omega-3 essential fatty acid docosahexaenoic acid (DHA) with potent inflammatory resolving and neuroprotective bioactivity. NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer's disease (AD) brain.

Neuroprotectin D1 (NPD1), the first-identified stereoselective bioactive product of DHA, exerts neuroprotection in models of experimental stroke by down-regulating brain ischemia reperfusion (BIR)-induced leukocyte infiltration, proinflammatory signaling, and infarct size.

2017年4月21日 · Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes cell survival under uncompensated oxidative stress (UOS). Our data demonstrate that NPD1...

2022年4月1日 · Neuroprotectin D1 (NPD1), a potent lipid anti-inflammatory mediator, is made in the brain and other peripheral immune cells on demand and counteracts inflammation and cell death [2]. NPD1 modulates pro- and anti-inflammatory pathways and mediators involved in ICH pathophysiology to promote tissue repair [[1], [2], [3]]. Thus, we hypothesized ...