Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto
2019年11月22日 · Here, we show that two other leukemogenic proteins, nucleoporin-fusion SET-Nup214 and the NPM1 mutant, NPM1c, which contains a nuclear export signal (NES) at its C …
Functions of the native NPM1 protein and its leukemic mutant
2024年12月17日 · NPM1 also contains 2 N-terminal nuclear export signal (NES) motifs that drive its nuclear export via interaction with the nuclear exporter XPO1 (CRM1) [3].
Mutant NPM1 directly regulates oncogenic transcription in acute …
Here, we show that NPM1c directly binds to specific chromatin targets, which are co-occupied by the histone methyltransferase KMT2A (MLL1). Targeted degradation of NPM1c leads to a …
Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic …
2022年11月15日 · The genome-wide recruitment of NPM1c to chromatin is dependent on the nuclear exporter CRM1 and its interaction with the nuclear export signal (NES) of NPM1c. …
NPM1-fusion proteins promote myeloid leukemogenesis through …
2024年10月23日 · In this study, we investigated the subcellular localization and leukemogenic potential of two rare NPM1-fusion proteins, NPM1::MLF1 and NPM1::CCDC28A. NPM1::MLF1 …
Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 …
2024年8月4日 · Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the …
Nucleophosmin: from structure and function to disease …
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. …
NPM1 mutation reprograms leukemic transcription network via …
2023年6月26日 · Hematopoietic-specific NPM1C+ knock-in alters TAD topology leading to disrupted regulation of the cell cycle as well as aberrant chromatin accessibility and homeotic …
Preclinical activity of a novel CRM1 inhibitor in acute myeloid ...
2012年8月30日 · Treatment of AML blasts with KPT-185 causes a reduction in the amount of CRM1 protein and shows a significant nuclear accumulation of CRM1 cargo proteins, such as …
Anti-proliferative activity of the NPM1 interacting natural product ...
2016年12月1日 · Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in …