2016年6月14日 · Glutathione S-transferase kappa 1 (Gstk1) was significantly downregulated in the five models, whereas myosin heavy chain 7 (Myh7), connective tissue growth factor (Ctgf), periostin (Postn), and reticulon 4 (Rtn4) were significantly upregulated.

2024年12月25日 · GSTK1 (Glutathione S-Transferase Kappa 1) is a Protein Coding gene. Diseases associated with GSTK1 include Acatalasemia and Cerebral Creatine Deficiency Syndrome 2. Among its related pathways are Metapathway biotransformation Phase I and II and Glutathione conjugation.

2021年9月6日 · Here, using the mammalian neonatal heart regeneration model, we show that Nrf1, a stress-responsive transcription factor encoded by the Nuclear Factor Erythroid 2 Like 1 (Nfe2l1) gene, is...

2024年10月25日 · GSTK1, which is upregulated most significantly in miR-124 knockdown neurons, reduces the oxygen consumption rate of neural cells. Collectively, our data highlight the roles of miR-124 in coordinating metabolic maturation at the early stages of neurogenesis and provide insights into potential metabolic regulators associated with human brain ...

2025年2月9日 · GSTK1 T/T genotype may be a novel risk factor for the prediction of overweight status in SCZ male patients. High glutathione-S-transferase is associated with type 2 diabetes mellitus.

跨膜转录因子Nrf1是CNC-bZIP家族中的重要成员,在维持细胞内氧化还原平衡、蛋白质稳态、内质网与线粒体稳定等功能中具有重要作用. 在小鼠不同的组织器官中敲除Nrf1后会导致多种疾病,如非酒精性脂肪肝、神经退行性疾病、糖尿病等. 近几年来,随着多种动物模型的运用及临床上的发现,Nrf1的新功能逐渐被揭示,尤其是参与棕色脂肪组织生热适应 (冷适应)、胆固醇代谢、糖代谢、内质网应激以及先天性去糖基化疾病发生等过程. 因此,为更好地理解Nrf1的作用,本文对其生物学功 …

该基因编码谷胱甘肽转移酶超家族的 kappa 类成员，该酶在细胞解毒中发挥作用。编码的蛋白质定位于过氧化物酶体并催化谷胱甘肽与广泛的疏水亚基结合，促进这些化合物从细胞中去除。可变剪接导致多个转录变体。[RefSeq 提供，2009 年 1 月]

2020年9月15日 · In this Perspective, we track the journey of NRF1 from the ER to the nucleus, with a special focus on the various molecular regulators it encounters along its way.

谷胱甘肽硫转移酶K1 (glutathione S-transferase kappa 1,GSTK1)是一个参与脂联素分泌和多聚化的关键蛋白,且在线虫中已经证实,GSTK1与能量产生和脂质代谢有关.同时GSTK1表达水平与肥胖呈负相关,并能缓解内质网应激诱导的脂联素水平下降,而且人GSTK1启动子的多态性与胰岛素分泌和脂肪沉积有关,因此,GSTK1可能成为一个治疗胰岛素抵抗及其相关的代谢疾病潜在的药物新靶点. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供 …

谷胱甘肽S转移酶kappa 1（GSTK1）是脂联素分泌和多聚化的关键调节剂。 在秀丽隐杆线虫中，GSTK1参与能量产生和脂质代谢。 同时，GSTK1水平与肥胖呈负相关。

2019年2月27日 · To gain an in-depth insight into distinct contributions of human Nrf1 isoforms (i.e. Nrf1α, Nrf1β and Nrf1γ) to the precision regulation of different subsets of its target genes, each of these...

2022年11月1日 · Nrf1α is indispensable for maintaining mitochondrial homeostasis. Glycolysis enhanced by hyper-active Nrf2 promotes ROS yield in Nrf1α-deficient cells. Negative regulation of UCP2 by Nrf1 and especially Nrf2 actually elevates ROS levels. Adaptive activation of mitochondrial stress by FCCP is blocked upon loss of Nrf1α.

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and ...

We found that the new liver-specific and inducible Nrf1 knockout mice accumulate lipid in the liver and exhibit a phenotype that resembles that of human nonalcoholic steatohepatitis (NASH).

Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report that NRF-1 regulates transcription of GABRB1 and that its core promoter contains a conserved canonical NRF-1 element responsible for sequence specific binding and transcriptional activation.

2020年9月14日 · Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS J 280, 3609–3620. Crossref, Medline, Google Scholar; Lee CS, Lee C, Hu T, Nguyen JM, Zhang J, Martin MV, Vawter MP, Huang EJ, Chan JY (2011).

Nuclear Respiratory Factor-1 (NRF-1) coordinates nuclear encoded respiratory chain expression with mitochondria gene transcription and replication [21]. NRF-1 recognition sites have been found in many genes encoding respiratory functional subunits, …

2022年10月24日 · We used western blot, immunofluorescence, Nissl staining, and Morris water maze to investigate the impact of NRF1 on brain damage and learning memory deficit by HIE. We performed ChIP and...

Glutathione transferase (GST) kappa, also named mitochondrial GST, is a very ancient protein family with orthologs in bacteria and eukaryotes. Both the structure and the subcellular localization of GSTK1-1, in mitochondria and peroxisomes, make this enzyme distinct from cytosolic GSTs.

2025年3月1日 · Background Cancer cell-secreted proteins play a critical role in tumor progression and chemoresistance by influencing intercellular interactions within the tumor microenvironment. Investigating the intratumoral functions of these secretory proteins may provide insights into understanding and treating chemoresistant cancers. This study aims to identify potential anticancer target(s) in ...