Downregulation of GSTK1 Is a Common Mechanism Underlying
2016年6月14日 · Glutathione S-transferase kappa 1 (Gstk1) was significantly downregulated in the five models, whereas myosin heavy chain 7 (Myh7), connective tissue growth factor (Ctgf), …
GSTK1 Gene - GeneCards | GSTK1 Protein | GSTK1 Antibody
2024年12月25日 · GSTK1 (Glutathione S-Transferase Kappa 1) is a Protein Coding gene. Diseases associated with GSTK1 include Acatalasemia and Cerebral Creatine Deficiency …
Nrf1 promotes heart regeneration and repair by regulating ... - Nature
2021年9月6日 · Here, using the mammalian neonatal heart regeneration model, we show that Nrf1, a stress-responsive transcription factor encoded by the Nuclear Factor Erythroid 2 Like 1 …
miR-124 coordinates metabolic regulators acting at early stages of ...
2024年10月25日 · GSTK1, which is upregulated most significantly in miR-124 knockdown neurons, reduces the oxygen consumption rate of neural cells. Collectively, our data highlight …
GSTK1 glutathione S-transferase kappa 1 [ (human)]
2025年2月9日 · GSTK1 T/T genotype may be a novel risk factor for the prediction of overweight status in SCZ male patients. High glutathione-S-transferase is associated with type 2 diabetes …
跨膜转录因子Nrf1的生物学功能研究进展<sub><sup>*</sup></s…
跨膜转录因子Nrf1是CNC-bZIP家族中的重要成员,在维持细胞内氧化还原平衡、蛋白质稳态、内质网与线粒体稳定等功能中具有重要作用. 在小鼠不同的组织器官中敲除Nrf1后会导致多种疾病, …
谷胱甘肽 S-转移酶 kappa 1（GSTK1）基因 | MCE
该基因编码谷胱甘肽转移酶超家族的 kappa 类成员，该酶在细胞解毒中发挥作用。编码的蛋白质定位于过氧化物酶体并催化谷胱甘肽与广泛的疏水亚基结合，促进这些化合物从细胞中去除。可 …
Regulation of NRF1, a master transcription factor of ... - PubMed
2020年9月15日 · In this Perspective, we track the journey of NRF1 from the ER to the nucleus, with a special focus on the various molecular regulators it encounters along its way.
谷胱甘肽硫转移酶K1研究进展 - 百度学术
谷胱甘肽硫转移酶K1 (glutathione S-transferase kappa 1,GSTK1)是一个参与脂联素分泌和多聚化的关键蛋白,且在线虫中已经证实,GSTK1与能量产生和脂质代谢有关.同时GSTK1表达水平与 …
谷胱甘肽S-转移酶κ1的进展。,Zhong nan da xue xue bao. Yi xue …
谷胱甘肽S转移酶kappa 1（GSTK1）是脂联素分泌和多聚化的关键调节剂。 在秀丽隐杆线虫中，GSTK1参与能量产生和脂质代谢。 同时，GSTK1水平与肥胖呈负相关。
Distinct isoforms of Nrf1 diversely regulate different subsets of its ...
2019年2月27日 · To gain an in-depth insight into distinct contributions of human Nrf1 isoforms (i.e. Nrf1α, Nrf1β and Nrf1γ) to the precision regulation of different subsets of its target genes, each …
Nrf1 is an indispensable redox-determining factor for …
2022年11月1日 · Nrf1α is indispensable for maintaining mitochondrial homeostasis. Glycolysis enhanced by hyper-active Nrf2 promotes ROS yield in Nrf1α-deficient cells. Negative …
NRF1 - Wikipedia
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some …
Transcription Factor Nrf1 Negatively Regulates the …
We found that the new liver-specific and inducible Nrf1 knockout mice accumulate lipid in the liver and exhibit a phenotype that resembles that of human nonalcoholic steatohepatitis (NASH).
Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity …
Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report that NRF-1 regulates …
Regulation of NRF1, a master transcription factor of proteasome …
2020年9月14日 · Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. …
Nuclear Respiratory Factor 1 - an overview - ScienceDirect
Nuclear Respiratory Factor-1 (NRF-1) coordinates nuclear encoded respiratory chain expression with mitochondria gene transcription and replication [21]. NRF-1 recognition sites have been …
Transcriptional regulation of NRF1 on metabotropic glutamate …
2022年10月24日 · We used western blot, immunofluorescence, Nissl staining, and Morris water maze to investigate the impact of NRF1 on brain damage and learning memory deficit by HIE. …
The glutathione transferase kappa family - PubMed
Glutathione transferase (GST) kappa, also named mitochondrial GST, is a very ancient protein family with orthologs in bacteria and eukaryotes. Both the structure and the subcellular …
Dickkopf-1 promotes tumor progression of gefitinib- resistant non …
2025年3月1日 · Background Cancer cell-secreted proteins play a critical role in tumor progression and chemoresistance by influencing intercellular interactions within the tumor …