Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and ...

2024年12月25日 · NRF1 (Nuclear Respiratory Factor 1) is a Protein Coding gene. Diseases associated with NRF1 include Oncocytoma and Skin Carcinoma In Situ. Among its related pathways are Cellular responses to stimuli and Transcriptional activation of …

2018年8月20日 · Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report that NRF-1 regulates transcription of GABRB1 and that its core promoter contains a conserved canonical NRF-1 element responsible for sequence specific binding and transcriptional activation.

Nuclear Respiratory Factor-1 (NRF-1) coordinates nuclear encoded respiratory chain expression with mitochondria gene transcription and replication [21]. NRF-1 recognition sites have been found in many genes encoding respiratory functional subunits, …

NRF-1 binds sequence-specifically to a GC-rich DNA element (RCGCRYGCGY). Early studies showed that this DNA sequence motif was mostly found in TATA-less promoters (3).

The IDE core promoter locates within a 32-bp region, which contains three CGGCG repeats and a nuclear respiratory factor 1 (NRF-1) binding motif. Sequential mutation analysis indicates that the NRF-1 binding motif is critical for IDE transcription initiation.

Nuclear respiratory factor 1 (NRF-1) was first discovered as an activator of the cytochrome c gene and was subsequently found to play a broader role in nuclear-mitochondrial interactions. We have now cloned a HeLa cDNA encoding NRF-1 using degenerate oligomers derived from tryptic peptide sequences …

Nuclear respiratory factor 1 (NRF-1) upregulates the expression and function of reduced folate carrier (RFC) at the blood-brain barrier. Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1. NRF-1 and HIF-1alpha contribute to modulation of human VDAC1 gene promoter during starvation and hypoxia in HeLa ...

factor 1 (NRF-1), a novel transcriptional activator defined by mutational and DNA binding analysis of the somatic cytochrome c promoter. Functional NRF-1 sites are now observed in several other recently isolated nuclear genes whose products function in the mitochondria.

2008年12月1日 · These NRF-1 target genes control cell adhesion, cell spreading, migration, proliferation, apoptosis, and tumor invasion. NRF-1 responds to redox signaling pathways through post-translational modifications and through its specific …