
Stat3 binds to mitochondrial DNA and regulates mitochondrial …
Current data suggest that mitochondrial Stat3 (mitoStat3) is necessary for maximal mitochondrial activity and for Ras-mediated transformation independent of Stat3 nuclear activity. We have …
NRF1 - Wikipedia
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some …
The ubiquitin ligase Pellino1 targets STAT3 to regulate ... - PubMed
2025年2月1日 · In a monocyte-specific Pellino1 knock-out mouse model, we find reduced macrophage migration and activation, leading to attenuated development of colitis and CAC in …
Stat3 Binds to mtDNA and Regulates Mitochondrial Gene …
2014年7月1日 · An increase in key nuclear-encoded metabolic genes, PGC-1α and NRF-1, was also observed in Stat3-null keratinocytes; however, no changes in nuclear-encoded electron …
Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity
2018年8月20日 · Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report …
Palliative potential of velutin against abamectin induced cardiac ...
2024年11月1日 · VLN was molecularly docked with certain protein complexes namely Nrf-2/Keap1, JAK1, STAT3, NF-kB and Bax. The docking results revealed that VLN possesses the …
Morin offsets PTZ-induced neuronal degeneration and cognitive ...
2022年9月15日 · The valuable effects were partly driven by diminishing ROS and modulating Keap-1/Nrf-2/HO-1 cue to turn off IL-6/p-JAK2/p-STAT3/GFAP cascade with the consequent …
Rutin and selenium nanoparticles protected against STZ-induced …
2022年10月15日 · Therefore, combining Ru with SeNPs has a potential renoprotective effect against DN by upregulating Nrf-2/HO-1 and downregulating Jak-2/Stat3 Pathways.
Nrf1 promotes heart regeneration and repair by regulating ... - Nature
2021年9月6日 · Our findings reveal that the adaptive stress response mechanism mediated by Nrf1 is required for neonatal heart regeneration and confers cardioprotection in the adult heart. …
STAT1 suppression requires NRF1 and NRF2 activation but
NFE2-related factor 1 (NFE2L1, NRF1) binds to similar cis-regulatory regions of antioxidant response elements as NRF2 (61), we sought to determine whether Nrf1 knockdown further …
Neuroprotective Effects of STAT3 Inhibitor on Hydrogen
2024年12月9日 · We observed that STAT3 inhibitors promote CREB phosphorylation, leading to the upregulation of immediate early genes such as c-Fos, c-Jun, Arc, Egr-1, NR4A1, and …
Role of STAT3 and NRF2 in Tumors: Potential Targets for …
Specifically, genetic ablation of Stat3 in murine as well as STAT3 in human cells leads to an increase of NF-κB-induced expression of CXCL1/IL-8, which contributes to infiltration of …
Inhibition of the STAT3/Fanconi anemia axis is synthetic ... - Nature
2025年3月4日 · After 10 min at RT, cells:beads were transferred to 50 μL of antibody solution (1:100 dilution of primary antibody (STAT3; ab171360 and H3K27ac; active motif; #39133) in …
The dual roles of STAT3 and NRF2 in cancer and their
Signal transducer and activator of transcription 3 (STAT3) and nuclear factor erythroid-derived 2-like 2 (NRF2, also known as NFE2L2), are two of the most complicated transcription regulators,...
Rutin and selenium nanoparticles protected against STZ
2022年10月15日 · Therefore, combining Ru with SeNPs has a potential renoprotective effect against DN by upregulating Nrf-2/HO-1 and downregulating Jak-2/Stat3 Pathways. Schematic …
NRF2 and STAT3: friends or foes in carcinogenesis? - ResearchGate
2023年3月31日 · NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspective will focus on the …
NRF1 (nuclear respiratory factor 1)
2008年12月1日 · NRF-1 / a-PAL (nuclear respiratory factor-1/a-palindrome-binding protein) is a transcription factor. It belongs to the NRF1/Ewg family. The optimal NRF-1 binding site is …
Regulation of NRF1, a master transcription factor of proteasome …
2020年9月14日 · Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. …
Special Issue “Role of STAT3 in Oncogenesis” - National Center for ...
They described the role of STAT3 and how STAT3 acts as an oncogene in cancer. They also explained six strategies that suppressed STAT3 signaling in cancer: (1) Suppressing STAT3 …
E3 ligase MIB1 regulates STAT1/P21 signaling via regulation
5 天之前 · Mind bomb 1 (MIB1) is an E3 ubiquitin ligase that promotes the polyubiquitination-mediated degradation of NOTCH ligands and plays an important role in vari ... In addition, …