Current data suggest that mitochondrial Stat3 (mitoStat3) is necessary for maximal mitochondrial activity and for Ras-mediated transformation independent of Stat3 nuclear activity. We have previously shown that Stat3 plays a pivotal role in epithelial carcinogenesis.

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and ...

2025年2月1日 · In a monocyte-specific Pellino1 knock-out mouse model, we find reduced macrophage migration and activation, leading to attenuated development of colitis and CAC in male mice. Mechanistically, Pellino1 targets STAT3 for lysine 63-mediated ubiquitination, resulting in pathogenic activation of STAT3 signaling.

2014年7月1日 · An increase in key nuclear-encoded metabolic genes, PGC-1α and NRF-1, was also observed in Stat3-null keratinocytes; however, no changes in nuclear-encoded electron transport chain gene transcripts or mtDNA copy number were observed. Collectively, our findings suggest a heretofore-unreported function for mitoStat3 as a potential mitochondrial ...

2018年8月20日 · Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report that NRF-1 regulates transcription of GABRB1 and that its core promoter contains a conserved canonical NRF-1 element responsible for sequence specific binding and transcriptional activation.

2024年11月1日 · VLN was molecularly docked with certain protein complexes namely Nrf-2/Keap1, JAK1, STAT3, NF-kB and Bax. The docking results revealed that VLN possesses the ability to effectively bind with all the targeted proteins with the strongest binding affinities observed in Nrf-2/Keap1, JAK1, STAT3, Bax and NF-kB, respectively.

2022年9月15日 · The valuable effects were partly driven by diminishing ROS and modulating Keap-1/Nrf-2/HO-1 cue to turn off IL-6/p-JAK2/p-STAT3/GFAP cascade with the consequent suppression of necroptosis and mitochondrial fission manifested by activating caspase-8 and turning off the TNF-α/TNFR-1/p-RIPK-1/p-RIPK-3/p-MLKL and p …

2022年10月15日 · Therefore, combining Ru with SeNPs has a potential renoprotective effect against DN by upregulating Nrf-2/HO-1 and downregulating Jak-2/Stat3 Pathways.

2021年9月6日 · Our findings reveal that the adaptive stress response mechanism mediated by Nrf1 is required for neonatal heart regeneration and confers cardioprotection in the adult heart. Heart disease...

NFE2-related factor 1 (NFE2L1, NRF1) binds to similar cis-regulatory regions of antioxidant response elements as NRF2 (61), we sought to determine whether Nrf1 knockdown further boosted Stat1...

2024年12月9日 · We observed that STAT3 inhibitors promote CREB phosphorylation, leading to the upregulation of immediate early genes such as c-Fos, c-Jun, Arc, Egr-1, NR4A1, and Homer1a, as well as BDNF. These genes are crucial for synaptic plasticity and long-term memory formation, suggesting that STAT3 inhibition may ameliorate cognitive impairments in ...

Specifically, genetic ablation of Stat3 in murine as well as STAT3 in human cells leads to an increase of NF-κB-induced expression of CXCL1/IL-8, which contributes to infiltration of myeloid cells as well as vascularization; while inhibiting CXCL1’s cognate receptor, CXCR2 can normalize tumor vascularization and microenvironment and reduce ...

2025年3月4日 · After 10 min at RT, cells:beads were transferred to 50 μL of antibody solution (1:100 dilution of primary antibody (STAT3; ab171360 and H3K27ac; active motif; #39133) in Wash buffer plus 0.1% ...

Signal transducer and activator of transcription 3 (STAT3) and nuclear factor erythroid-derived 2-like 2 (NRF2, also known as NFE2L2), are two of the most complicated transcription regulators,...

2022年10月15日 · Therefore, combining Ru with SeNPs has a potential renoprotective effect against DN by upregulating Nrf-2/HO-1 and downregulating Jak-2/Stat3 Pathways. Schematic diagram summarizing the possible renoprotective mechanisms of Rutin (Ru) in combination with selenium nanoparticles (SeNPs) in STZ-induced nephropathy in rats.

2023年3月31日 · NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspective will focus on the complex interplay of...

2008年12月1日 · NRF-1 / a-PAL (nuclear respiratory factor-1/a-palindrome-binding protein) is a transcription factor. It belongs to the NRF1/Ewg family. The optimal NRF-1 binding site is (T/C)GCGCA (C/T)GCGC (A/G). DNA size 144.26 kb; mRNA size 2578 bp 12 exons. It is widely expressed, and strongest expression is in skeletal muscle. Nucleus.

2020年9月14日 · Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS J 280 , 3609–3620. Crossref , Medline , Google Scholar

They described the role of STAT3 and how STAT3 acts as an oncogene in cancer. They also explained six strategies that suppressed STAT3 signaling in cancer: (1) Suppressing STAT3 upstream proteins, (2) Targeting the SH2 domain of STAT3, (3) Blocking STAT3 DNA-binding sites, (4) Inhibiting the STAT3 N-terminal domain, (5) Suppressing STAT3 mRNA ...

5 天之前 · Mind bomb 1 (MIB1) is an E3 ubiquitin ligase that promotes the polyubiquitination-mediated degradation of NOTCH ligands and plays an important role in vari ... In addition, FGF3 interacts with FGFR1, which regulates STAT3 phosphorylation, leading to spontaneous breast cancer (Chen et al. 2023). ... (NRF) grants funded by the Korean government ...