Current data suggest that mitochondrial Stat3 (mitoStat3) is necessary for maximal mitochondrial activity and for Ras-mediated transformation independent of Stat3 nuclear activity. We have …

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some …

2025年2月1日 · In a monocyte-specific Pellino1 knock-out mouse model, we find reduced macrophage migration and activation, leading to attenuated development of colitis and CAC in …

2014年7月1日 · An increase in key nuclear-encoded metabolic genes, PGC-1α and NRF-1, was also observed in Stat3-null keratinocytes; however, no changes in nuclear-encoded electron …

2018年8月20日 · Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report …

2024年11月1日 · VLN was molecularly docked with certain protein complexes namely Nrf-2/Keap1, JAK1, STAT3, NF-kB and Bax. The docking results revealed that VLN possesses the …

2022年9月15日 · The valuable effects were partly driven by diminishing ROS and modulating Keap-1/Nrf-2/HO-1 cue to turn off IL-6/p-JAK2/p-STAT3/GFAP cascade with the consequent …

2022年10月15日 · Therefore, combining Ru with SeNPs has a potential renoprotective effect against DN by upregulating Nrf-2/HO-1 and downregulating Jak-2/Stat3 Pathways.

2021年9月6日 · Our findings reveal that the adaptive stress response mechanism mediated by Nrf1 is required for neonatal heart regeneration and confers cardioprotection in the adult heart. …

NFE2-related factor 1 (NFE2L1, NRF1) binds to similar cis-regulatory regions of antioxidant response elements as NRF2 (61), we sought to determine whether Nrf1 knockdown further …

2024年12月9日 · We observed that STAT3 inhibitors promote CREB phosphorylation, leading to the upregulation of immediate early genes such as c-Fos, c-Jun, Arc, Egr-1, NR4A1, and …

Specifically, genetic ablation of Stat3 in murine as well as STAT3 in human cells leads to an increase of NF-κB-induced expression of CXCL1/IL-8, which contributes to infiltration of …

2025年3月4日 · After 10 min at RT, cells:beads were transferred to 50 μL of antibody solution (1:100 dilution of primary antibody (STAT3; ab171360 and H3K27ac; active motif; #39133) in …

Signal transducer and activator of transcription 3 (STAT3) and nuclear factor erythroid-derived 2-like 2 (NRF2, also known as NFE2L2), are two of the most complicated transcription regulators,...

2022年10月15日 · Therefore, combining Ru with SeNPs has a potential renoprotective effect against DN by upregulating Nrf-2/HO-1 and downregulating Jak-2/Stat3 Pathways. Schematic …

2023年3月31日 · NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspective will focus on the …

2008年12月1日 · NRF-1 / a-PAL (nuclear respiratory factor-1/a-palindrome-binding protein) is a transcription factor. It belongs to the NRF1/Ewg family. The optimal NRF-1 binding site is …

2020年9月14日 · Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. …

They described the role of STAT3 and how STAT3 acts as an oncogene in cancer. They also explained six strategies that suppressed STAT3 signaling in cancer: (1) Suppressing STAT3 …

5 天之前 · Mind bomb 1 (MIB1) is an E3 ubiquitin ligase that promotes the polyubiquitination-mediated degradation of NOTCH ligands and plays an important role in vari ... In addition, …