Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing.

2024年12月25日 · NRG1 (Neuregulin 1) is a Protein Coding gene. Diseases associated with NRG1 include Schizophrenia 6 and Lung Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by ERBB2 KD Mutants. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.

NRG1（神经调节蛋白1），是隶属于表皮生长因子（epidermal growth factor, EGF）家族，是一类介导细胞间相互作用的信号蛋白，主要表达于脑、心脏、乳腺等组织中，参与组织细胞的发育和成熟。 NRG1蛋白质结构主要包括：胞内区结构、跨膜区、近膜序列、胞外的EGF样结构域、免疫球蛋白样结构域和氨基酸序列（如下图）。 NRG1基因通过选择性启动子的使用和选择性的mRNA剪接，会形成4个亚型：I型NRG1~VI型NRG1，其中最主要的是I型~III型3种不同的NRG1亚型。 …

NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation. Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.

Neuregulin (NRG) and ErbB receptor structures. NRG gene products share a structural characteristic for the extracellular epidermal growth factor (EGF) domain and it differentiates this subfamily from other members of the EGF family.

2023年3月20日 · NRG1（神经调节蛋白1，又称为ARIA、HRG、GGF、NDF），是 表皮生长因子 （epidermal growth factor, EGF）家族成员之一，分子量为44 kD。 NRG1蛋白质结构主要包括：胞内区结构、跨膜区、近膜序列、胞外的EGF样结构域、免疫球蛋白样结构域和氨基酸序列。 NRG1基因通过选择性启动子的使用和剪接，会形成4个亚型：I型NRG1~VI型NRG1，其中最主要的是I型~III型3种不同的NRG1亚型。 所有类型的NRG1都含有α、β两种EGF样结构域。 EGF …

Oncogenic gene fusions are hybrid genes that result from structural DNA rearrangements, leading to deregulated activity. Fusions involving the neuregulin-1 gene (NRG1) result in ErbB-mediated pathway activation and therefore present a rational candidate for targeted treatment.

2025年2月8日 · The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing.

Recent research has highlighted NRG1’s pivotal role in the genesis and progression across a spectrum of tumors, influencing molecular perturbations across various tumor-associated signaling pathways. This review provides a concise overview of NRG1, including its expression patterns, configuration, and fusion partners.

Neuregulin-1 (NRG1) is an important regulator of ErbB-mediated pathways involved in cancer development. Recently, there have been several studies analyzing NRG-1 gene fusions engaged in altering the dimerization of HER family proteins and the consecutive results of their activation in different types of cancer.