2006年4月2日 · Here, we report that nucleoredoxin (NRX)4, a thioredoxin (TRX) family protein, interacts with Dvl. Overexpression of NRX selectively suppresses the Wnt–β-catenin pathway …

Here, we report that nucleoredoxin (NRX), a thioredoxin (TRX) family protein, interacts with Dvl. Overexpression of NRX selectively suppresses the Wnt-beta-catenin pathway and ablation of …

2010年11月9日 · Biochemical analyses reveal that Dvl is rapidly degraded by accelerated ubiquitination in NRX−/− mouse embryonic fibroblasts, and they fail to activate Wnt/β-catenin …

Dvl and NRX is inhibited by H 2 O 2 treatment. These data suggest a relationship between the Wnt– β-catenin pathway and redox signalling through redox-sensitive association of NRX with …

We previously reported that nucleoredoxin (NRX) directly binds to Dishevelled (Dvl) and inhibits its signaling function in culture cells [4]. To further elucidate the function of NRX in vivo, we …

The binding of Dvl to NRX depends on NRX activity, as mutation of two catalytic cysteines disrupts binding to Dvl. Furthermore, binding is inhibited by treatment with hydrogen peroxide …

NRX usually interacts with Dishevelled (Dvl), an essential adaptor protein for Wnt signalling, and blocks the activation of the Wnt pathway. Oxidative stress causes dissociation of NRX from …

2006年6月1日 · Here, we report that nucleoredoxin (NRX), a thioredoxin (TRX) family protein, interacts with Dvl. Overexpression of NRX selectively suppresses the Wnt-beta-catenin …

Here, we report that nucleoredoxin (NRX), a thioredoxin (TRX) family protein, interacts with Dvl. Overexpression of NRX selectively suppresses the Wnt-beta-catenin pathway and ablation of …

2008年8月28日 · In co-injection experiments of Dvl and NRX mRNA, NRX suppresses the Dvl-induced bent-axis phenotype. Over-expression or depletion of NRX also suppresses the …