Dysregulation of mitochondrial α-ketoglutarate dehydrogenase …
2025年2月26日 · Using an unbiased metabolomic analysis of purified mitochondria, we identified alterations in α-ketoglutarate dehydrogenase (KGDH) pathway upon loss of PD-linked …
Dysregulation of mitochondrial α-ketoglutarate dehydrogenase …
2025年2月26日 · Using an unbiased metabolomic analysis of purified mitochondria, we identified alterations in α-ketoglutarate dehydrogenase (KGDH) pathway upon loss of PD-linked …
Control of histone demethylation by nuclear-localized α ... - Science
We explored the function of nuclear KGDH in controlling genome-wide histone methylation and gene expression in Arabidopsis using RNA sequencing and chromatin immunoprecipitation …
三羧酸循环的过程与酶（二） - 知乎专栏
KGDH与PDH同属于一个家族（2-氧代酸脱氢酶复合体家族），所以催化机制与PDH很相似，E1为α-酮戊二酸脱氢酶，E2为二氢硫辛酰胺琥珀酰转移酶，E3为二氢硫辛酰胺脱氢酶。 KGDH不仅 …
Alpha-ketoglutarate dehydrogenase: a target and generator of …
Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of α …
新型修饰大揭秘 ③ | 揭开线粒体能量代谢的新篇章：琥珀酰化修饰 …
利用景杰生物独家开发的 琥珀酰化修饰泛抗体和组蛋白位点特异性琥珀酰化抗体，研究人员发现KAT2A-KGDH复合体可以提高组蛋白 H3K79的琥珀酰化 水平，影响基因的表达调控，最终 促 …
KAT2A coupled with the α-KGDH complex acts as a histone H3 ... - PubMed
2017年12月14日 · Here we show that the α-ketoglutarate dehydrogenase (α-KGDH) complex is localized in the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, …
A new role for α-ketoglutarate dehydrogenase complex: …
The E2k subunit of KGDHC is a trans-succinylase enzyme which is required for KGDH activity (Gibson et al. 2015). Loss of this enzyme decreases succinylation and the presence of α …
Science | 何跃辉教授团队揭示核定位的α-酮戊二酸脱氢酶复合体调 …
光照促进与tca循环相关的酶kgdh进入植物细胞核，调控jmjs的组蛋白去甲基化酶活性 （https://www.science.org/doi/10.1126/science.adf8822）。
Science | 何跃辉团队揭示核定位的α-酮戊二酸脱氢酶复合体调控组蛋白去甲基化的分子机制|KGDH…
2023年7月23日 · 通过荧光蛋白标记以及核质蛋白分离与检测等方法，研究人员发现少量kgdh的三个亚基存在于拟南芥细胞核中，并且在细胞核中检测到了kgdh全酶的催化活性，这说明植物细 …