NS-398 is a COX-2 inhibitor used in the study of the function of cyclooxygenases. [2]

NS-398 是一种非甾体类抗炎剂，具有解热作用，可用于缓解疼痛的研究。 NS-398 能够选择性地抑制 COX-2 的活性， IC50 值为 3.8 μM，在 100 μM 的浓度下，对 COX-1 的活性没有作用。 * Please select Quantity before adding items. • Nat Neurosci. 2024 Jan 2. [Abstract] • Nat Commun. 2024 Sep 12;15 (1):7996. [Abstract] • Acta Pharm Sin B. 2023 Oct 28. • EBioMedicine. 2019 Jul;45:341-350. [Abstract]

NS-398 is a novel anti-inflammatory and analgesic agent which produces much fewer gastrointestinal lesions in rats. Recently, two forms of cyclooxygenase have been identified: a COX-1 first purified from ram seminal vesicles and a …

NS-398，是一种选择性环氧合酶-2(cyclooxygenase-2,COX-2,即PGH synthase-2)的抑制剂。 NS-398对于人COX-2的 IC50根据不同的文献约为0.1-1.77μM，而对于人COX-1的IC50根据不同文献仅约为75-100μM。

NS-398 is a C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2. It has a role as a cyclooxygenase 2 inhibitor and an antineoplastic agent.

NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and >100 μM for COX-2 and COX-1, respectively). Orally active. Anti-inflammatory, antipyretic, analgesic and non-ulcerogenic in vivo. Induces apoptosis and cell cycle arrest. Store at Room Temperature. The product can be stored for up to 12 months.

1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent tha …

ns 398 是一种选择性环氧合酶2抑制剂（cox-2 和 cox-1 的 ic50 值分别为 3.8 和 >100 μm）。 口服活性。 ns 398在体内具有抗炎、解热、镇痛和非溃疡性。 诱导细胞凋亡和细胞周期停滞。 图1.ns 398化学结构 ns …

NS-398和化疗药物塞来昔布都是环氧化酶-2（COX-2）抑制剂，EGCG和NS-398的联合治疗促进了前列腺癌细胞（LNCaP、PC-3和CWR22Rnu1）中Bax、pro-caspase-6和pro-caspase-9以及裂解的PARP的表达，并降低了前列腺特异性抗原和IGF-I水平，从而诱导凋亡并抑制小鼠肿瘤的生长。