Structural basis for antibody inhibition of flavivirus NS1 ... - Science
2021年1月8日 · Here, we present three crystal structures of full-length dengue virus NS1 complexed with a flavivirus–cross-reactive, NS1-specific monoclonal antibody, 2B7, at …
A broadly protective antibody that targets the flavivirus NS1
2021年1月8日 · The flavivirus nonstructural protein 1 (NS1) is a promising vaccine antigen with low ADE risk but has yet to be explored as a broad-spectrum therapeutic antibody target. …
Structural basis of Zika virus NS1 multimerization and human
2024年4月25日 · Here, we present high-resolution cryoEM structures of ZIKV recombinant secreted NS1 (rsNS1) and its complexes with three human monoclonal antibodies (AA12, …
Structural insights into the distinct protective mechanisms of …
2024年10月1日 · To elucidate the NS1 antigenic sites and how anti-NS1 antibodies protect against ZIKV infection, we first assessed complexes formation of the ZIKV NS1 tetramer with …
How NS1 Antibodies Prevent Severe Flavivirus Disease
2021年7月1日 · The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies …
Structural basis of Flavivirus NS1 assembly and antibody recognition
We describe the previously unidentified high-resolution structure of the C-terminal half of West Nile virus (WNV) and Dengue virus-1 (NS1 172–352) NS1 proteins and a separate structure of …
Structural biology of flavivirus NS1 protein and its antibody …
2024年7月1日 · This review focuses on the recent advances in the structural landscape of the secreted NS1 (sNS1) and its complex with monoclonal antibodies (mAbs). NS1 forms an …
多聚体分泌型 NS1 的冷冻电镜结构，这是登革出血热的主要因 …
细胞内二聚体 ns1 (ins1) 构成病毒复制复合体的一部分。 先前的研究表明，细胞外分泌的 NS1 (sNS1) 是导致 DHF 的主要因素，以六聚体形式存在。 iNS1 的结构已被充分表征，但 sNS1 的 …
Here, we present three crystal structures of full-length dengue virus NS1 complexed with a flavivirus–cross-reactive, NS1-specific monoclonal antibody, 2B7, at resolutions between 2.89 …
Structural basis of Flavivirus NS1 assembly and antibody
2014年3月18日 · NS1 (172-352) assembles as a unique rod-shaped dimer composed of a 16-stranded β-platform flanked on one face by protruding connecting loops. We also determined …