2021年8月31日 · Our findings provide insights into the Nsp2-host interplay and indicate that Nsp2 may play important roles in SARS-CoV-2 infection and serve as a potential drug target for anti-SARS-CoV-2 drug development.

The alphavirus nonstructural protein 2 (nsP2) functions as a protease, which is critical for the establishment of a productive viral infection by enabling accurate processing of the nsP123 polyprotein. Owing to the essential role played by nsP2 in the alphavirus infectious process, it is also a valuable therapeutic target.

2024年4月15日 · 冠状病毒非结构蛋白2（nonstructural protein 2, nsp2）是病毒基因Orf1ab编码的多聚蛋白在病毒木瓜样蛋白酶作用下，经切割后形成的成熟加工产物。

2023年3月30日 · A proteomic analysis of SARS-CoV-2/human proteins interaction revealed viral Nsp2 and initiation factor eIF4E2, but a role of Nsp2 in regulating translation is still controversial.

2024年1月30日 · For the first time, we found that SARS-CoV-2-encoded nonstructural protein 2 (NSP2) can be secreted from the cells, where it is synthesized. Brefeldin A and H89, inhibitors of ER/Golgi secretion pathways, did not inhibit NSP2 secretion. NSP2 is likely secreted via an unconventional secretory pathway.

The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report an atomic model for full-length Nsp2 obtained by combining ...

2021年9月27日 · 综上所述，nsp2 N端结构是全面了解SARS-CoV-2 nsp2结构-功能关系的第一步。 针对SARS-CoV-2全球大流行，我们的研究结果对于充分利用nsp2作为进一步开发抗病毒靶点和药物设计具有重要意义。

Our findings provide insights into the Nsp2–host interplay and indicate that Nsp2 may play important roles in SARS-CoV-2 infection and serve as a potential drug target for anti-SARS-CoV-2 drug development.

冠状病毒非结构蛋白2（nonstructural protein 2, Nsp2）是病毒基因Orf1ab编码的多聚蛋白质在病毒木瓜样蛋白酶作用下，经切割后形成的成熟加工产物。 Nsp2的研究较少，其在病毒复制相关的生命周期、与宿主相互作用等过程中发挥的主要作用至今未得到阐明。

冠状病毒非结构蛋白2 (nonstructural protein 2,Nsp2)是病毒基因Orf1ab编码的多聚蛋白质在病毒木瓜样蛋白酶作用下,经切割后形成的成熟加工产物。 Nsp2的研究较少,其在病毒复制相关的生命周期、与宿主相互作用等过程中发挥的主要作用至今未得到阐明。