Monoclonal Antibody for studying NUP98. Validated for IF, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, NUP98 (C39A3) Rabbit Monoclonal Antibody (CST #2598) is ready to ship.

NUP98 (L205) Antibody detects endogenous levels of NUP98 protein. The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

Monoclonal Antibody for studying NUP98. Validated for IF. Highly specific and rigorously validated in-house, NUP98 (C39A3) Rabbit Monoclonal Antibody (Alexa Fluor® 488 Conjugate) (CST #13358) is ready to ship.

Both NUP98 (5) and lamins (6) are located within the nuclear envelope (also known as the nuclear membrane). NUP98 is a component of the nuclear pore complex. Lamin A and lamin C are fibrous proteins contributing to nuclear structural and transcriptional regulation.

JARID1C (D29B9) Rabbit mAb detects endogenous levels of total JARID1C protein. The antibody does not cross-react with other JARID proteins, including JARID1A, JARID1B and JARID1D.

2023年8月29日 · Here, we demonstrate that the nuclear bodies of NUP98::HOXA9 and SET::NUP214 promote the condensation of mixed lineage leukemia 1 (MLL1), a histone methyltransferase essential for the maintenance of HOX gene expression. These nuclear bodies are robustly associated with MLL1/CRM1 and co-localized on chromatin.

2017年12月14日 · Cell lines and primary macrophages were washed in PBS, lysed in RIPA buffer (CST-9806) supplemented with a protease inhibitor cocktail (Roche), spun at 14000G for 10 min and cleared lysates mixed with NuPAGE LDS Sample Buffer and heated at 95°C for 5 mins.

最新的世界卫生组织分类（WHO 5th）和国际共识分类（ICC）将携带KMT2A和NUP98重排的AML定义为不同的疾病实体。 因此，了解具有驱动基因改变的pAML的生物学和临床特征，对于改善pAML的分类及治疗十分重要。 pAML与成人AML（aAML）有许多共同的临床和病理学特征，也存在遗传差异。 基于基因变异相关临床结果的积累，人们能够根据详细的突变图谱对aAML进行风险分层；但由于pAML的罕见性以及基因变异相关临床结果的缺乏，目前针对该疾病的风险分 …

2024年4月17日 · 为了探究化疗引起心脏损伤的机制，研究人员构建了MLL-AF9、NUP98-HOXA9 AML动物模型，并在此基础上模拟临床用药方案给予诱导化疗，小动物磁共振和心脏超声检查发现AML荷瘤小鼠在接受柔红霉素 (DNR)化疗后会出现心脏功能下降。 PET/CT结果显示心脏脂肪酸摄取降低，葡萄糖摄取增加，ATP含量下降。 有趣的是，无瘤小鼠在接受相同剂量的DNR化疗后却不会出现上述改变，提示化疗后肿瘤的变化在化疗诱导的心脏功能障碍和代谢紊乱中起到了关键 …

Monoclonal Antibody for studying NUP98. Validated for IF, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, NUP98 (C39A3) Rabbit Monoclonal Antibody (CST #2598) is ready to ship.