2011年2月18日 · We identify phosphorylation of the GLFG-repeat nucleoporin Nup98 as an important step in mitotic NPC disassembly. Mitotic hyperphosphorylation of Nup98 is …

2023年4月26日 · Here we directly probed conformations of the vital FG-NUP98 inside NPCs in live cells and in permeabilized cells with an intact transport machinery by using a synthetic …

研究结果证实，野生型核孔蛋白(wild type nucleoporin，wt-Nup)98需要脱离NPC进入细胞核核浆内，才能发挥其对有丝分裂、核浆运输等过程的调控作用；而Nup98融合基因编码的Nup98蛋白 …

2011年12月8日 · NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia …

2024年5月7日 · Here, we combine phase separation experiments and site-directed mutagenesis to gain insight into the contribution of specific FG-repeats of Nup98, an important FG-NUP of …

2023年2月10日 · Nup98 FG repeat domains comprise hydrophobic FG motifs linked through uncharged spacers. FG motifs capture nuclear transport receptors (NTRs) during nuclear pore …

2012年1月1日 · Together our immuno-EM data suggest that Nup98 is anchored within the center of the NPC by its C-terminal domain, whereas its N-terminal GLFG domain exhibits structural …

Nup98, which exhibits transcription-dependent mobility at the NPC but can also bind chromatin away from the nuclear envelope, is frequently involved in chromosomal translocations in a …

2024年12月25日 · NUP98 (Nucleoporin 98 And 96 Precursor) is a Protein Coding gene. Diseases associated with NUP98 include Hematologic Cancer and Childhood Acute Myeloid Leukemia. …

2010年2月5日 · We analyzed genomic interactions of full-length nucleoporins Nup98, Nup50, and Nup62 and nucleoplasmic and NPC-tethered forms of Nup98. We found that nucleoporins …