2023年7月7日 · NUT carcinoma is a rare cancer that forms when issues with a gene called NUTm1 cause healthy cells to become malignant. It usually forms in your head, neck and lungs. NUT carcinoma is a fast-growing cancer that’s difficult to treat. Scientists are currently researching new treatment options — like targeted therapy — in clinical trials.

Necrotic upper tips1 (nut1) is a transcription factor that mimics tassel blasting when mutated. We show that NUT1 protein localizes to the developing protoxylem where it activates genes necessary for reinforcing the secondary cell wall, and thus enables these cells to withstand the high negative pressures required for long-distance water movement.

该研究首先从转座子Activator 中分离出隐性nut1-m1突变体。研究发现，即使在水分充足的条件下，nut1-m1突变体也表现出干旱和热胁迫表型，并且这种表型在花后叶片和雄穗尖端更为严重

2024年12月25日 · NUTM1 (NUT Midline Carcinoma Family Member 1) is a Protein Coding gene. Diseases associated with NUTM1 include Spindle Cell Sarcoma and Nut Midline Carcinoma. Among its related pathways is Chromatin Regulation / Acetylation. An important paralog of this gene is NUTM2D. Plays a role in the regulation of proliferation.

2020年8月17日 · NUT-1 (NUT family member 1 protein) immunocytochemistry performed on cell blocks demonstrated characteristic speckled nuclear staining in tumor cells. Pulmonary NC presents as a poorly differentiated carcinoma with focal to …

2022年3月15日 · Nuclear protein in testis (NUT) carcinoma (NC), is a rare carcinoma characterized by a chromosomal rearrangement involving the NUT midline carcinoma family member 1 (NUTM1) gene, also known as NUT gene, located on chromosome 15q14 (1 – 5).

2022年3月25日 · 睾丸核蛋白（NUT）是NUTM1基因（位于15号染色体长臂）的蛋白产物，在生理条件下，在睾丸减数分裂后的生精细胞中表达，对男性生育能力至关重要，NUT失活可导致男性不育。 免疫组织化学染色显示在卵母细胞中也可存NUT 弱表达。 在生精细胞和NUT癌细胞中，NUT已被证明通过直接相互作用强烈增强其下游效应物（组蛋白乙酰转移酶p300）的活性。 当NUTM1基因与参与转录调控的基因融合时，可成为一组新兴肿瘤的致癌驱动因素。 最初发现 …

2019年2月5日 · NUT carcinoma (previously known as NUT midline carcinoma) is a rare, aggressive malignancy defined by rearrangement of the NUTM1 (NUT midline carcinoma family member 1) gene on 15q14.

NUT carcinoma (NC) is a rare, aggressive subtype of squamous cell carcinoma defined by rearrangement of the NUTM1 (aka NUT) gene. NC is driven by NUT-fusion oncoproteins resulting from chromosomal translocation, most commonly BRD4-NUT. This is a nearly uniformly lethal cancer affecting patients of all ages, but predominantly teens and young adults.

NUT1 (also called MED5) encodes a component of the tail module of the Mediator transcriptional regulation complex. The Mediator complex is highly conserved from yeast to human, and is a central player in the transcriptional regulation of protein-coding genes, being required for nearly all transcription by RNA polymerase II (RNAPII).