Analysis using liquid NaFl suggests that the TBUT test has excellent diagnostic accuracy and that a cut-point of 5.3 to 6.0 seconds is the optimum to differentiate normals from dry eye persons. Keywords: tear breakup time, tear stability, breakup time, fluorescein, dry eye, test efficacy

Analysis using liquid NaFl suggests that the TBUT test has excellent diagnostic accuracy and that a cut-point of 5.3 to 6.0 seconds is the optimum to differentiate normals from persons with dry eye. Little difference in TBUT was found using the 3 clinical methods with video recordings.

Efficacy study: Subjects were randomized to the Dry Eye Test (DET), Standard Strip (SS) and 2.0 microliters of 1.0% NaFl, on separate days. A masked examiner measured TBUTs from video recordings. Verification study: Subjects were analyzed, using NaFl volumes of 5.0 microliters of 2.0% and 2.0 microliters of 1.0% NaFl for TBUT. Raw values were ...

2017年1月1日 · NaFl TBUT was increased in both the fish oil and krill oil groups, reaching statistical significance at days 60 and 90, compared with placebo. On average, NaFl TBUT improved from 8.1±1.1 and 5.1±0.5 seconds at baseline to 11.9±2.0 and 9.2±0.9 seconds at the study end point in the fish oil and krill oil groups, respectively.

2018年2月1日 · Hypotonic 0.4% sodium hyaluronate eye drops produced a greater improvement in Rose Bengal staining, Nafl staining, TBUT and impression cytology grade than isotonic 0.4% sodium hyaluronate eye drops amongst individuals with Sjögren’s syndomen [34]. However, participants who preferred TheraTears did not have significantly different tear ...

2020年8月1日 · During image acquisition, certain topographers require the addition of sodium fluorescein (NaFl) dye to the tear film. This study investigates the effect of NaFl dye on corneal topography and tear surface quality.

2016年2月24日 · 近日，由墨尔本大学 Downie 完成的一项关于自动泪膜表面特征破裂时间（automated tear film surface quality breakup time，TFSQ-BUT）的研究发表于 IOVS。 这一回顾性研究纳入了 45 名受试者，其中包括 28 名已确诊 DED 的患者，17 名健康人作为对照组。 确诊 DED 的标准为：眼表疾病指数评分（OSDI）≥ 18，泪液渗透压 ≥ 316 mOsmol/L，连续三次荧光素钠泪膜破裂时间（NaFl-BUT）测定至少有一次少于 10 秒。 检查包括泪液分泌试验、泪液渗 …

Assessment of tear break up time (TBUT) is a core measure of tear stability and its measurement is a major cornerstone of clinical tests for dry eye 1, 2, 3 as an indication of the rate of tear loss by evaporation. This measurement has the potential to capture the combined contributions of lipid, mucin and aqueous deficiencies to tear ...

Little difference in TBUT was found using the 3 clinical methods with video recordings. Analysis using liquid NaFl suggests that the TBUT test has excellent diagnostic accuracy and that a cut-point of 5.3 to 6.0 seconds is the optimum to differentiate normals from persons with dry eye.

Tear break-up time (TBUT) also known as tear film break-up time (TFBUT) is the time taken for the first dry spot to appear on the cornea after a complete blink. TFBUT measurement is an easy and fast method used to assess the stability of tear film .