Growth hormone receptor (GHR) is a transmembrane protein consisting of 620 amino acids. The receptor is part of the Type I cytokine receptor family of receptors. GHR exists in two forms as a full length membrane-bound receptor and as a soluble GH binding protein (GHBP).

2024年12月25日 · GHR (Growth Hormone Receptor) is a Protein Coding gene. Diseases associated with GHR include Laron Syndrome and Growth Hormone Insensitivity, Partial. Among its related pathways are Endochondral ossification with …

（英語：)是一种由人类 基因 编码的 蛋白质 [1]，GHR的 直系同源 物 [2] 广泛存在于各种 哺乳动物 中。 此基因编码的蛋白是结合 生长激素 的跨膜受体。 生长激素受体能与 SGTA [3] 、 PTPN11 [4][5] 、 JAK激酶2 [6][7][8] 、 SOCS1 [9] 和 CISH [9] 发生 交互作用。 基因曾作为动物 核DNA （英语：nuclear DNA） 系统发育标记 [2]，对其10号外显子基因多态性的探究第一次阐释了 啮齿目 主要类群间的亲缘关系 [10][11][12]。

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling. Gene Ontology (GO) annotations organized by slimming set.

2024年12月10日 · In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

The GHR gene provides instructions for making a protein called the growth hormone receptor. This receptor is embedded in the outer membrane of cells throughout the body and is most abundant in liver cells.

Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

GHR的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为这个基因编码Ⅰ型细胞因子受体家族的类型，这是对于生长激素跨膜受体的一个成员。 生长激素的受体结合的导致受体的二聚化和细胞内和细胞间信号转导途径导致生长的激活。 在这种基因突变与拉伦综合征，也称为生长激素不敏感综合征（GHIS）的病症特征为矮小身材关联。 在人类和兔，但不啮齿动物，通过从成熟生长激素受体蛋白的胞外配体结合域的蛋白水解切割产生的生长激素结合蛋 …

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, …