Studies conflict regarding the importance of the fluoroquinolone-resistant North American pulsed-field gel electrophoresis type 1 (NAP1) strain in Clostridium difficile infection (CDI) outcome. We describe strain types causing CDI and evaluate their association with patient outcomes. CDI cases were identified from population-based surveillance.

We provide here an in-depth review of one particular strain/ribotype 027, commonly known as NAP1/B1/027 or North American pulsed-field gel electrophoresis type 1, restriction endonuclease analysis type B1, polymerase chain reaction ribotype 027, which has shown a much higher recurrence rate than other strains.

Conclusions: NAP1 was the most prevalent strain and a predictor of severe disease, severe outcome, and death. Strategies to reduce NAP1 prevalence, such as antibiotic stewardship to reduce fluoroquinolone use, might reduce CDI morbidity. Keywords: Clostridium difficile; clinical outcomes; epidemiology; strain typing.

Introduction: Multiply recurrent Clostridium difficile infection (mrCDI) incidence increased from 2001-2012 along with an increasing prevalence of the NAP1 strain of C. difficile. NAP1 genotype positivity is reported to be associated with failure of standard of care (SOC) antibiotic therapy.

Here, we describe for the first time, the implication of NAP-1 (Nucleosome assembly protein 1), a histone chaperone that has been involved in nuclear transport, transcription regulation, and chromatin remodeling, in telomere biology.

2025年1月13日 · Nucleosome assembly protein 1 (NAP1) is a key player in chromatin dynamics, influencing DNA packaging and access within the cell nucleus. This impacts gene expression and genomic stability. Understanding NAP1’s role offers insights into biological mechanisms and potential therapeutic targets for diseases linked to chromatin misregulation.

2009年8月1日 · Recent outbreaks of Clostridium difficile infection (CDI) in North America and in Europe with very high case-fatality rates have been associated with infection by North American Pulsed Field Type I (NAP-1) isolates. This study examined whether NAP-1 strains are associated with worse outcomes of CDI in a nonepidemic, nosocomial setting.

2024年12月25日 · NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NAP1L1 include Human Herpesvirus 8 and Chikungunya. Among its related pathways are Overlap between signal transduction pathways contributing to LMNA laminopathies and VEGFA-VEGFR2 signaling.

1 Section of Molecular Biology, University of California, San Diego, La Jolla, California 92093-0347, USA. PMID: 14712724 DOI: 10.1016/S0076-6879(03)71037-4

2024年3月5日 · HIV-1 Rev interacting protein, nucleosome assembly protein 1-like 1 (NAP1L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NAP1L1 is decreased by RRE