Deeper evaluation of a single-cell foundation model - Nature
1 天前 · The value of foundation models for single-cell RNA-sequencing data will instead be showcased through superior performance on more challenging fine-tuning tasks for which simple models do not excel ...
Construction of a human cell landscape at single-cell level | Nature
2020年3月25日 · Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex systems 1. However, a comprehensive single-cell atlas has not been achieved for humans. Here...
Single-cell integration reveals metaplasia in inflammatory gut ... - Nature
2024年11月20日 · Using bulk deconvolution with our single-cell data as a reference (Methods), we found significantly higher proportions of INFLAREs in Crohn’s disease and ulcerative colitis samples and ...
Single-cell RNA sequencing (RNA-seq), which profiles gene expression, is the most common technique. Other methods detail processes such as meth-ylation, genetic variation, protein...
the past year that have described single-cell proteomics strategies, tools and preliminary findings. And more are coming. In 2018, Nikolai Slavov, a systems biologist at Northeastern University...
Label-free single-cell RNA multiplexing leveraging genetic ... - Nature
2024年12月5日 · Single cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell ...
The single-cell transcriptional landscape of mammalian ... - PubMed
Here we investigate the transcriptional dynamics of mouse organogenesis at single-cell resolution. Using single-cell combinatorial indexing, we profiled the transcriptomes of around 2 million cells derived from 61 embryos staged between 9.5 and 13.5 days of gestation, in a single experiment.
张鹏/王晨飞/孙毅/曾安团队合作揭示非小细胞肺癌免疫联合化疗的 …
1 天前 · 近日，同济大学附属上海市肺科医院张鹏团队联合同济大学生命科学与技术学院王晨飞团队，同济大学医学院孙毅团队与中国科学院生化细胞所曾安团队在《自然·遗传学》（Nature Genetics）杂志在线发表题为“Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small cell lung cancer ...
From single cells to neural circuits | Science - AAAS
2023年11月2日 · Linking neuronal subpopulations defined by single-cell transcriptomics to specific neural circuits—e.g., those activated by stimuli such as hunger or fear—has remained challenging. I came face-to-face with this challenge in my efforts to understand the neural circuits engaged by epidural electrical stimulation (EES).
Dictionary of immune responses to cytokines at single-cell
Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets 1-3.A myriad of studies have highlighted their central role in immune function 4-13, yet we lack a global view of the cellular responses of each immune cell type to each cytokine.To address this gap, we created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of ...
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