2024年12月25日 · NCAPD3 (Non-SMC Condensin II Complex Subunit D3) is a Protein Coding gene. Diseases associated with NCAPD3 include Microcephaly 22, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are Cell Cycle, Mitotic and RNA Polymerase I Promoter Opening.

2022年6月11日 · Our data demonstrated that NCAPD3 promoted glucose metabolism reprogramming and enhanced Warburg effect in colorectal tumorigenesis and CRC progression. These findings reveal a novel mechanism underlying NCAPD3 mediated CRC cell growth and provide new targets for CRC treatment.

NCAPD3是凝缩蛋白II的一个HEAT-repeat亚基，在凝缩蛋白介导的染色体动力学中起主导作用，但在淋巴瘤中尚未被研究。 本研究旨在揭示NCAPD3在弥漫性大b 细胞淋巴瘤 (DLBCL)中的分子功能及机制。 研究者通过公共数据库和临床标本评估NCAPD3的表达及临床意义。 通过染色体扩散、共 免疫 沉淀 (co-IP)、质谱 (MS)和染色质免疫沉淀 (ChIP)分析来阐明NCAPD3在DLBCL中的作用和机制。 NCAPD3表达上调，并与DLBCL的不良结局相关. 图片来源： …

2024年4月1日 · Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves...

两种凝缩蛋白均包含 2 个不变的染色体结构维护 (SMC) 亚基 SMC2 (MIM 605576) 和 SMC4 (MIM 605575) ，但它们包含不同组的非 SMC 亚基。 NCAPD3 是定义凝缩蛋白 II 的 3 个非 SMC 亚基之一 (Ono 等人，2003 [PubMed 14532007]) 。 [OMIM 提供，2008 年 3 月]

Condensin-2 complex subunit D3 (CAP-D3) also known as non-SMC condensin II complex subunit D3 (NCAPD3) is a protein that, in humans, is encoded by the NCAPD3 gene. [5][6][7][8] CAP-D3 is a subunit of condensin II, a large protein complex involved in …

2024年3月4日 · NCAPD3, a HEAT-repeat subunit of condensin II, plays a dominant role in condensin-mediated chromosome dynamics but remains unexplored in lymphoma. Objectives: The study aims to unravel the molecular function and mechanism of NCAPD3 in diffuse large B-cell lymphoma (DLBCL).

2025年2月9日 · NCAPD3 promotes prostate cancer progression by up-regulating EZH2 and MALAT1 through STAT3 and E2F1. NCAPD2 and NCAPD3 expression levels have been confirmed to be significantly up-regulated in the intestinal mucosa of …

2024年4月21日 · Non-SMC condensin II complex subunit D3 (NCAPD3) plays a crucial role in the occurrence of many diseases. However, its role in GC remains unexplored. Materials and Methods: The Cancer Genome Atlas (TCGA) database, clinical samples, and cell lines were used to analyze NCAPD3 expression in GC.

Our report demonstrated that NCAPD3 is an androgen-responsive gene and upregulated by androgen/AR axis and involved in AR-promoted progression of PCa, suggesting a potential role of NCAPD3 in the PCa development.