Nebulin [5] is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. Nebulin in humans is coded for by the gene NEB. It is a very large protein …

Nebulin is a giant 600- to 900-kDa filamentous protein that is an integral component of the skeletal muscle thin filament. Its functions have remained largely nebulous because of its large size …

Nebulin, encoded by NEB, is a giant skeletal muscle protein of about 6669 amino acids which forms an integral part of the sarcomeric thin filament. In recent years, the nebula around this …

Nebulin is a family of giant actin-binding protein of 600–900 kDa, present exclusively in skeletal muscle sarcomere and absent from cardiac muscle in verebrates (Zhang et al., 1996; Kruger …

2020年1月25日 · Nebulin, encoded by NEB, is a giant skeletal muscle protein of about 6669 amino acids which forms an integral part of the sarcomeric thin filament. In recent years, the …

2010年10月18日 · Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of …

Summary: The giant protein nebulin is a multifunctional protein that impacts skeletal muscle function in diverse ways. Actin is the prominent protein in most eukaryotic cells. Control of …

2024年12月25日 · This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. …

Nebulin is a large sarcomeric protein that is coextensive with the actin filament of the skeletal muscle sarcomere. A ) Gel electrophoresis of human and mouse soleus muscle extracts …

2021年3月3日 · Nebulin is crucial for physiological force levels; it controls thin filament length and stiffness, promotes thin filament activation, and enhances cross-bridge recruitment (Kiss et al., …