2019年12月2日 · Among E3s, neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) has been shown to play a critical role in modulating the proliferation, migration,...

NEDD4 is an E3 ubiquitin ligase enzyme, that targets proteins for ubiquitination. [7] NEDD4 is, in eukaryotes, a highly conserved gene, and the founding member of the NEDD4 family of E3 …

2024年12月25日 · NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with NEDD4 include Liddle Syndrome 1 and Charcot-Marie-Tooth …

2019年12月2日 · Among E3s, neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) has been shown to play a critical role in modulating the proliferation, migration, …

2007年1月12日 · Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal …

2020年4月1日 · Neural precursor cell-expressed developmentally downregulated gene 4-1 (NEDD4-1, also known as NEDD4) is a founding member of the NEDD4 family of E3 ligases …

Among E3s, neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) has been shown to play a critical role in modulating the proliferation, migration, and invasion of …

2025年1月31日 · NEDD4 (表达发育下调的神经元前体细胞4)，也称为NEDD4-1，是NEDD4家族中的一种E3 Ub (泛素)连接酶，含有HECT结构域。 它通过不同靶点的泛素化在各种发病机制中 …

2007年1月12日 · Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and purified its ubiquitin ligase as HECT-domain protein NEDD4-1. In cells …

2023年9月25日 · Nedd4 is a HECT domain-containing E3 ubiquitin ligase with a wide range of protein targets, the dysregulation of which has been implicated in myriad pathologies, …