NEDD4–2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and …

NEDD4 can bind and ubiquitinate the epithelial sodium channel (ENaC), leading to down-regulation of sodium channel activity. [18] However, in vivo studies have implicated the …

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 is an enzyme (ubiquitin ligase) of the NEDD4 family. In human the protein is …

2023年5月10日 · Our data identify Nedd4-2 as the first E3 ubiquitin ligase involved in ACE2 ubiquitination in Ang-II-mediated hypertension. We demonstrate the pivotal role of ACE2 on …

2009年6月26日 · Of the nine mammalian members of this family, Nedd4 and its close relative, Nedd4-2, represent the ancestral ligases with strong similarity to the yeast, Rsp5. In …

2021年7月22日 · Neural precursor cell expressed developmentally down-regulated 4 ligase (Nedd4-2) is an E3 ubiquitin ligase that targets proteins for ubiquitination and...

Nedd4-2 is (in part) the converging point for both aldosterone and insulin signals, mediated through Sgk1 (serum glucocorticoid-inducible kinase) and Akt (also called protein kinase B, …

2024年2月28日 · NEDD4-2 belongs to the Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family, which is characterized by a C2 domain, 2–4 …

2015年2月15日 · NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which …

In the current study, we established that PKC-induced inhibition of OAT3 transport activity in monkey kidney COS-7 cells and in human kidney HEK293 cells occurred through an …