Nefopam, sold under the brand name Acupan among others, is a centrally acting, non-opioid painkilling medication, with central stimulant and sympathomimetic properties that is primarily used to treat moderate to severe pain.

盐酸奈福泮为一种新型的非麻醉性镇痛药，兼有轻度的解热和肌松作用，阻断电压敏感性钠通道（IC50=27µM）并调节啮齿动物的谷氨酸能传递，所以不具有非甾体抗炎药的特性，亦非阿片受体激动剂，对中、重度疼痛有效，对呼吸抑制作用较轻。 对循环系统无抑制作用。 无耐受和依赖性。 产生作用时常有嗜睡、恶心、出汗、头昏、头疼、肠胃不适等，但一般持续时间不长。 偶见口干、眩晕、皮疹、烦躁。 注射液对血管刺激较强。 本品为5-甲基-1-苯基-3,4,5,6-四氢-1H-2,5- …

用于术后止痛、癌症痛、急性外伤痛的治疗,亦适用于急性胃炎、胆道蛔虫症、输尿管结石等内脏平滑肌绞痛 [1] 可提高疼痛阈，为非麻醉性和非吗啡受体激动剂的镇痛药，其作用不被纳洛酮所阻断，镇痛作用强于吗啡、阿司匹林，起效缓慢但较维持时间持久，且无耐受性和成瘾性。 另外兼有解热、局部麻醉和消炎作用，可减缓炎症早期的毛细血管渗透性的增高，对炎性水肿、渗出及炎症增殖的肉芽组织增生均有抑制作用。 [2] 口服和肌内注射易吸收，口服给药后30min起效，血浆 …

Find out how nefopam treats pain and how to take it. NHS medicines information on nefopam – what it's used for, side effects, dosage and who can take it.

Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs. It is effective by the oral and parenteral routes, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that …

Nefopam is an atypic molecule with a chemical structure closer to antihistamines than to opioids. It has various anticholinergic actions on descending serotinergic pathways and GABA receptors.

盐酸奈福泮片（Nefopam Hydrochloride Tablets），用于术后止痛、癌症痛、急性外伤痛。 亦用于 急性胃炎 、 胆道蛔虫症 、 输尿管结石 等 内脏 平滑肌 绞痛 。

2023年2月23日 · Nefopam is a painkiller which is prescribed to relieve moderate pain which is not being controlled by other painkillers such as paracetamol or aspirin. Although it is not fully understood how it works, it is thought to interrupt the way pain messages are sent to …

2024年1月9日 · Nefopam is a potent and rapidly-acting analgesic. It is totally distinct from other centrally-acting analgesics such as morphine, codeine, pentazocine and propoxyphene. Unlike the narcotic agents, nefopam has been shown not to cause respiratory depression. There is no evidence from pre-clinical research of habituation occurring with nefopam.

View nefopam hydrochloride information, including dose, uses, side-effects, renal impairment, pregnancy and contra-indications.