它由含有 nemo (也称为 ikkγ，nf-κb 信号必需调节剂) 的 ikk 复合物 的激活介导，后者又指定经典的 iκb 进行降解，随后释放 nf-κb 二聚体用于核易位。(注：ikk 复合物包括三个重要的成员，nemo，ikkα，ikkβ)。

nemo：在经典的nf-κb信号通路中， nemo是必需的。nemo可能通过与ikkβ和ikkα的直接作用而介导ikk复合物的组装, 并且还能促进iκb 蛋白与ikk激酶复合物的相互作用。

非经典 NF-κB 激活途径包括 p52 前体和 p100 的磷酸化、将二者加工为成熟蛋白以及 RelB:p52 异源二聚体转移至细胞核并激活靶标基因。 该途径涉及的 IKK 复合物由两个 IKKα 亚基组成，不含 NEMO。

2010年12月28日 · Decades of research has revealed that transcriptionally functional NF-κB dimers are activated by two major pathways, canonical and non-canonical. Both pathways involve the release of NF-κB...

2016年3月11日 · The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis.

2020年4月14日 · Our efforts reveal that a tertiary protein structure mimic of NEMO is necessary for potent inhibition. The rationally designed mimic engages vFLIP directly causing complex disruption, protein...

2009年1月11日 · Here, we demonstrate that LUBAC activates the canonical NF-κB pathway by binding to NEMO (NF-κB essential modulator, also called IKKγ) and conjugates linear polyubiquitin chains onto specific...

2012年7月6日 · Nuclear factor-κB (NF-κB) essential modulator (NEMO), a component of the inhibitor of κB kinase (IKK) complex, controls NF-κB signaling by binding to ubiquitin chains. Structural studies of NEMO provided a rationale for the specific binding between the UBAN (ubiquitin binding in ABIN and NEMO) domai …

2025年3月11日 · NEMO protein contains a c-terminal ZF domain that is required for its DNA damage–induced small ubiquitin-like modifier (SUMO)ylation and subsequent NF-kB activation (24, 43). Moreover, NEMO mutants that are defective in SUMOylation failed to be translocated to the nucleus upon genotoxic stress .

2023年9月7日 · We discovered that nuclear factor kappa B (NF-κB) essential regulator NF-κB effector molecule (NEMO) is recruited to damaged mitochondria in a Parkin-dependent manner in a time course similar to recruitment of the structurally …