Nephrin is a transmembrane protein that is a structural component of the slit diaphragm. [5] It is present on the tips of the podocytes as an intricate mesh connecting adjacent foot processes . Nephrin contributes to the strong size selectivity of the slit diaphragm, [ 6 ] [ 7 ] however, the relative contribution of the slit diaphragm to ...

2007年9月1日 · Nephrin is a transmembrane protein (∼185–200 kDa) with a short intracellular domain, and an extracellular domain with eight distal IgG-like motifs and one proximal fibronectin type III-like motif (Figure 2 a). The length of the entire extracellular domain of nephrin is ∼35 nm. Each IgG-like motif contains two cysteine residues forming a ...

NPHS1 粘附分子，nephrin： 该基因编码细胞粘附分子免疫球蛋白家族的一个成员，该家族在肾脏的肾小球滤过屏障中发挥作用。 该基因主要在肾组织中表达，该蛋白是一种在肾小球足细胞裂隙隔膜处发现的 1 型跨膜蛋白。

Nephrin is a key molecule in podocytes to maintain normal slit diaphragm structure. Nephin interacts with many other podocyte and slit diaphragm protein and also mediates important cell signaling pathways in podocytes. Loss of nephrin during the development leads to the congenital nephrotic syndrome …

Nephrin 属于免疫球蛋白超家族分子，为一跨膜蛋白，人Nephrin 长1 241个氨基酸残基，包括胞内区、跨膜区和胞外区。其C 端为胞内区，N 端为胞外区。胞外区从N 端开始含有6 个连续的Ig 区,再接1 个间隔区，接着又有2 个Ig区,随后为1 个纤连蛋白Ⅲ区。

（一）Nephrin特异性表达于肾小球足细胞，是一种重要的足细胞裂孔膜结构蛋白，其基因突变可导致先天性肾病综合征。 目前没有合适的Nephrin基因敲除小鼠模型，Nephrin对肾脏足细胞发育的影响及机制目前尚未完全清楚。

Glomerular podocytes are critical for the barrier function of the glomerulus in the kidney and their dysfunction causes protein leakage into the urine (proteinuria). Nephrin is a key podocyte protein, which regulates the actin cytoskeleton via tyrosine phosphorylation of its cytoplasmic domain.

nephrin为细胞黏附分子中的免疫球蛋白超家族成员,特异性 表达于肾小球,是肾小球上皮细胞裂孔隔膜的主要组成成份之一.nephrin对于维持肾小球滤过屏障的完整性起关键作用,其基因突变可引起芬兰型先天性肾 病综合征(CNF).本文就nephrin的结构,功能及其在CNF,实验性 ...

Nephrin作为肾小球足细胞膜上的跨膜蛋白,是足细胞裂隙膜重要的结构分子.近来发现,nephrin分子细胞内段的酪氨酸残基在被酪氨酸激酶fyn(属Src激酶家族成员)磷酸化后,能激活下游信号分子,形成足细胞内特有的信号转导通路,如nephrin-podocin-MAPK-AP-1、nephrin-CD2AP-PI3K-Akt/PKB ...

Nephrin is a type-1 transmembrane protein belonging to the immunoglobulin superfamily. It comprises eight immunoglobulin-like motifs followed by a fibronectin type III domain, a short transmembrane region and a cytoplasmic carboxy-terminal part.