2025年2月25日 · Magnesium (Mg 2+) is a key regulatory ion of N-methyl-ᴅ-aspartate (NMDA) receptors, including conferring them to function as coincidence detectors for excitatory …

2022年12月11日 · The N-methyl-D-aspartate (NMDA) receptor is a glutamate receptor, the human brain's primary excitatory neurotransmitter. It plays an integral role in synaptic …

NMDARs are tetrameric receptors incorporating two obligatory GluN1 subunits that bind glycine or D-serine and are encoded by a single gene, GRIN1, with eight splice variants.

2025年3月6日 · Structural analysis revealed the asymmetric architecture of the GluN1-N2A-N2B receptor throughout the extracellular to the transmembrane layers. Moreover, the …

近日，法国波尔多大学Julien P. Dupuis等人在Neuron发表重要综述，总结了神经可塑性和认知相关的 突触后NMDAR信号 的新维度，如NMDAR复合物的纳米级组织、其活性依赖性再分配和 …

DOI: 10.1016/j.neuron.2023.05.002 Abstract N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in synaptogenesis, synaptic maturation, long-term plasticity, …

2025年4月2日 · Read the latest articles of Neuron at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature. Skip to main content. Journals & Books ...

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium permeability that play important roles in many aspects of the biology of higher organisms. They are critical …

2025年3月10日 · 相关研究成果以《镁离子对NMDA受体多重调控机制的结构基础》为题，发表在《神经元》（Neuron）上。研究工作得到科技创新2030-重大项目、国家自然科学基金和中国 …

2025年2月25日，中国科学院脑科学与智能技术卓越创新中心 （神经科学研究所） 竺淑佳 团队在 Neuron 期刊在线发表了文章 Structural insights into the diverse actions of magnesium on …