2019年9月18日 · Here we show that neuron and glioma interactions include electrochemical communication through bona fide AMPA receptor-dependent neuron–glioma synapses. Neuronal activity also evokes...

2025年2月19日 · Using whole-cell patch-clamp electrophysiology, in vivo optogenetics and patient-derived orthotopic xenograft models, we identified functional, tumour-promoting GABAergic neuron-to-glioma...

2024年12月6日 · Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has been hampered by a lack of technologies. Here, we adapted retrograde tracing using rabies viruses to investigate and manipulate neuron-tumor networks.

An increasing body of evidence has become available to reveal the synaptic and functional integration of glioma into the brain network, facilitating tumor progression. The novel discovery of glioma-neuronal interactions has fundamentally challenged ...

2023年5月3日 · Using intracranial brain recordings during lexical retrieval language tasks in awake humans together with site-specific tumour tissue biopsies and cell biology experiments, we find that gliomas...

1 天前 · Neuron–glioma interactions. a, Neurons regulate glioma progression by secreting paracrine growth factors and by forming synaptic connections with glioma cells. In turn, synaptogenic factors secreted by gliomas can increase neuronal activity in the tumor microenvironment. b, After the IGF1 derived from neurons binds to the IGF1R on the ...

2025年1月20日 · Glioma patients suffer devastating neurological complications. Using mouse models, the authors show that glioma induces neuronal mTOR activity, alters translation of synaptic genes, reduces dendritic spines and inhibitory synapses, and causes hyperexcitability and stimulus-evoked discharges.

We developed a system utilizing rabies virus–based monosynaptic tracing to visualize neurons that synapse onto human gliomas implanted in the mouse brain. This approach maps and quantitatively analyzes glioma-innervating neurons (GINs) across the brain and overcomes previous barriers to their molecular and electrophysiological analysis.

Here we show that neuron and glioma interactions include electrochemical communication through bona fide AMPA receptor-dependent neuron-glioma synapses. Neuronal activity also evokes non-synaptic activity-dependent potassium currents that are amplified by gap junction-mediated tumour interconnections, forming an electrically coupled network.

2024年2月1日 · Neuronal activity can drive progression of high-grade glioma by mediating mitogen production and neuron-glioma synaptic communications. Glioma stem cells (GSC) also play a significant role in progression, therapy resistance, and recurrence in glioma, which implicates potential cross-talk between neuronal activity and GSC biology.