Neurturin (NRTN) is a protein that is encoded in humans by the NRTN gene. Neurturin belongs to the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors, which regulate the survival and function of neurons.

2023年3月21日 · 神经秩蛋白(Neurturin)属于神经营养因子中的胶质细胞线衍生神经营养因 子（GDNF）家族，该家族调节神经元的生存和功能。Neurturin 作为一种生长因子，与它的同源物 persephin、artemin 和 GDNF 一起属于 TGF-beta…

Neurturin protein, vital in neurobiology, is key to supporting sympathetic neuron survival and implicated in regulating the central nervous system (CNS). It influences neural growth, stability, and may modulate non-neuronal cell populations.

Neurturin is a protein that belongs to the GDNF family of ligands and functions as a trophic factor. It has a high sequence homology to GDNF and signals through the RET receptor. Neurturin can provide neuroprotection for degenerating nigrostriatal neurons by binding to the GFRα1 receptor.

2024年12月25日 · NRTN (Neurturin) is a Protein Coding gene. Diseases associated with NRTN include Hirschsprung Disease 1 and Cholestasis, Benign Recurrent Intrahepatic, 2. Among its related pathways are MAPK family signaling cascades and Nervous system development.

Animal-Free Neurturin Protein, Mouse (His) 是重组的 无动物源神经营养因子蛋白，由 E. coli 表达，带有 N-His 标签。 Neurturin 蛋白在神经生物学中至关重要，是支持交感神经元存活的关键，并参与调节中枢神经系统 (CNS)。 它影响神经生长、稳定性，并可能调节非神经元细胞群。 Neurturin 是一种通过二硫键连接的同型二聚体，可维持神经元存活之外的多种细胞功能的结构完整性。 Animal-Free Neurturin Protein, Human (His) 是重组的 无动物源神经营养因子蛋白，由 …

PGC-1α1 increased muscle secretion of neurturin, which was sufficient and necessary for the effects of muscle PGC-1α1 on NMJ formation. Conclusions: Our findings indicate that neurturin is a mediator of PGC-1α1-dependent retrograde signaling from muscle to motor neurons.

1996年12月5日 · This factor, neurturin, is structurally related to glial-cell-line-derived neurotrophic factor (GDNF). These factors can each activate the MAP kinase signalling pathway in cultured sympathetic neurons and support the survival of sympathetic neurons, as well as of sensory neurons of the nodose and dorsal root ganglia.

2008年9月16日 · Neurturin (NRTN) belongs to the glial cell line-derived neurotrophic factor (GDNF) family, the members of which are distant relatives of the TGF-β superfamily (Kotzbauer et al. 1996). The GDNF family consists of the four ligands GDNF, NRTN, artemin, and persephin which preferentially bind to one of the co-receptors GFRalpha1–4, respectively ...

2025年1月4日 · Title: Refolding and purification of cGMP-grade recombinant human neurturin from Escherichia coli inclusion bodies. We have reconstituted the complete extracellular region of the RET signaling complex together with Neurturin (NRTN) and GFRalpha2 and determined its structure at 5.7-A resolution by cryo-EM.