The administration of antiepileptic drugs (AEDs) is the first treatment of epilepsy, one of the most common neurological diseases. Therapeutic guidelines include newer AEDs as front-line drugs; monotherapy with new AEDs is delivered in Japan. While ...

Nowadays, several novel antiepileptic agents are in different drug development stages. 56, 57 These drugs may have better safety, efficacy, and compatible pharmacokinetic properties. It is urgent to improve animal models and search for new drug targets to treat patients with refractory epilepsy. 57 , 58

2021年9月17日 · As a follow-up to the initial Standard and New Antiepileptic Drugs (SANAD) trials, which found lamotrigine to be superior to carbamazepine, oxcarbazepine, topiramate and gabapentin in time to treatment failure in patients with mostly focal epilepsy , and valproate to be superior to lamotrigine and topiramate in patients with mostly generalized ...

Abstract. Over the last two decades a total of 11 antiepileptic drugs (AEDs) have been introduced to the US market. Randomized, placebo-controlled trials have yielded information about each drug’s efficacy, tolerability, and safety profile; however, few studies have compared the newer generation AEDs directly with the older generation.

2024年7月22日 · Recently, the scientific community changed the designation of ‘antiepileptic drugs’ ... New avenues for antiepileptic drug discovery and development. Nat. Rev. Drug Discov. 12, 757–776 (2013).

The U.S. Food and Drug Administration today approved XCOPRI (cenobamate tablets) to treat partial-onset seizures in adults. “XCOPRI is a new option to treat adults with partial-onset seizures ...

2023年10月9日 · New drug offers relief for treatment-resistant epilepsy patients Date: October 9, 2023 Source: NYU Langone Health / NYU Grossman School of Medicine

Newer antiepileptic drugs may control seizures more effectively, but their significant potential for serious side effects requires a thorough knowledge of the drugs and careful consideration of ...

2016年5月15日 · The administration of antiepileptic drugs (AEDs) is the first treatment of epilepsy, one of the most common neurological diseases. Therapeutic guidelines include newer AEDs as front-line drugs; monotherapy with new AEDs is delivered in Japan. While about 70% of patients obtain good seizure control b …

2024年10月19日 · Since the 2004 publications, the US Food and Drug Administration (FDA) approved 6 new third-generation AEDs and 2 older AEDs. This update reviews new evidence for efficacy of these AEDs in managing treatment-resistant (TR) focal epilepsies and generalized epilepsies (GEs) in children and adults. Reaffirmed on October 19, 2024. >Codeveloped with the American Epilepsy Society.</p>