NFAT and NF-kappaB proteins are members of a superfamily of transcription factors whose activity plays a crucial role in the activation, proliferation and apoptosis of lymphocytes. Both types of factors share a number of properties, including …

In the studies described in this report, we demonstrated a physical interaction between multiple Ets and NF-kappaB/NFAT proteins both in vitro and in activated normal human T cells. This interaction is mediated by the Ets domain of Ets proteins and the C-terminal region of the Rel homology domains of NF-kappaB/NFAT proteins.

2023年6月23日 · Here, we show that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/nuclear factor κB (NF-κB), integrate through a dynamic and combinatorial strategy to fine-tune T cell response genes.

2012年3月8日 · We identified a novel transcriptional regulatory mechanism whereby NFκB and NFAT directly interact and synergistically promote transcriptional activation in cardiomyocytes. We show that the p65 subunit of NFκB coimmunoprecipitates with NFAT in cardiomyocytes, and this interaction maps to the RHD within p65.

Like Rel/NF-kappaB proteins but unlike the calcium-regulated NFAT proteins, NFAT5 is constitutively dimeric, and dimerization is essential for DNA binding and transcriptional activity. Using dominant-negative proteins that inhibit NFAT5 dimerization, we show that NFAT5 regulates expression of the TNFalpha and lymphotoxin-beta genes in ...

活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类 转录因子 家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快速诱导其表达的转录因子而被发现。 NFAT在多种动物组织和细胞中广泛表达，是细胞内多条 信号转导通路 的关键调节点，在免疫系统、神经系统发育、轴突生长以及神经系统疾病中也发挥着重要作用。 NFAT蛋白的基本结构.

2024年6月27日 · 活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类转录因子家族，最初是在活化的 T 细胞中作为一种能够结合在人白介素 - 2（Interleukin-2， IL-2）的启动子上的快速诱导其表达的转录因子而被发现。 NFAT 在多种动物组织和细胞中广泛表达， 是细胞内多条信号转导通路的关键调节点， 在免疫系统 、 神经系统发育、轴突生长以及神经系统疾病中也发挥着重要作用。 NFAT 蛋白的基本结构.

2020年10月12日 · Recently, we have shown a pivotal role for the nuclear factor of activated T-cell cytoplasmic member 3 (NFATc3) transcription factor in modulating pulmonary macrophage function in LPS-induced acute lung injury (ALI) pathogenesis.

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems.

2012年4月4日 · To determine the potential functional interaction between NFAT and NFκB signaling pathways in cardiomyocytes and its role in cardiac hypertrophy and remodeling. Here we identified a novel transcriptional regulatory mechanism whereby NFκB and NFAT directly interact and synergistically promote transcriptional activation in cardiomyocytes.