NFAT proteins: key regulators of T-cell development and function
2005年6月1日 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and …
STIM1-mediated NFAT signaling synergizes with STAT1 to control …
2025年2月21日 · Here, we report a patient with an intronic loss-of-function mutation in STIM1, which abolishes SOCE and causes immunodeficiency. We demonstrate that SOCE promotes …
一文搞定|活化的T细胞核内因子 (NFAT)的结构及其功能 - 知乎
活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类 转录因子 家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快 …
NFAT - Wikipedia
Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of …
Identification of Novel Nuclear Factor of Activated T Cell (NFAT ...
2016年11月11日 · Our analyses suggest that NFAT proteins can cooperatively bind with RUNX1 and CREB1 proteins to cognate DNA recognition motifs. Furthermore, we provide evidence …
Identification of three NFAT binding motifs in the 5'-upstream …
2002年12月6日 · We have identified three NFAT consensus sequences (5'-GGAAA-3') in the 5'-upstream region of the human CD3gamma gene at: -124 to -120 (NFAT(gamma1)), -384 to …
Cell cycle and apoptosis regulation by NFAT transcription ... - Nature
2016年4月21日 · Three main small conserved regions can be identified among the TADs of NFAT variants and will be referred to as the N-terminus motif (black square, Figure 3), central motif …
Identification of Three NFAT Binding Motifs in the 5′-Upstream …
A search of the 5′-upstream region and exon 1 of the humanCD3γ gene revealed three potential binding motifs for NFAT family proteins (NFAT γ1, NFAT γ2, and NFAT γ3). The NFAT γ1 …
The LxVP and PxIxIT NFAT Motifs Bind Jointly to ... - ScienceDirect
2014年7月8日 · NFAT’s regulatory domain can remain bound to the phosphatase by its LxVP motif. Our findings show that the LxVP-derived peptide binds to a site overlapped with the …
The NFAT Family: Structure, Regulation, and Biological Functions
2010年1月1日 · This chapter sheds light on the structure, regulation, and biological functions of the NFAT family, which is a family of transcription factors. The primordial NFAT family member …