2005年6月1日 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and NFAT4 might also control thymocyte...

2025年2月21日 · Here, we report a patient with an intronic loss-of-function mutation in STIM1, which abolishes SOCE and causes immunodeficiency. We demonstrate that SOCE promotes nuclear factor of activated T...

活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类 转录因子 家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快速诱导其表达的转录因子而被发现。 NFAT在多种动物组织和细胞中广泛表达，是细胞内多条 信号转导通路 的关键调节点，在免疫系统、神经系统发育、轴突生长以及神经系统疾病中也发挥着重要作用。 NFAT蛋白的基本结构.

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems.

2016年11月11日 · Our analyses suggest that NFAT proteins can cooperatively bind with RUNX1 and CREB1 proteins to cognate DNA recognition motifs. Furthermore, we provide evidence that the activity of the NFAT-associated kinases mTOR and CHEK1 has an impact on NFAT's potential to activate transcription.

2002年12月6日 · We have identified three NFAT consensus sequences (5'-GGAAA-3') in the 5'-upstream region of the human CD3gamma gene at: -124 to -120 (NFAT(gamma1)), -384 to -380 (NFAT(gamma2)), and +450 to +454 (NFAT(gamma3)) from the first transcription initiation site.

2016年4月21日 · Three main small conserved regions can be identified among the TADs of NFAT variants and will be referred to as the N-terminus motif (black square, Figure 3), central motif (gray square) and...

A search of the 5′-upstream region and exon 1 of the humanCD3γ gene revealed three potential binding motifs for NFAT family proteins (NFAT γ1, NFAT γ2, and NFAT γ3). The NFAT γ1 motif is located in a DNase I-hypersensitive site that has been designated as the putative promoter for CD3γ (71, 86, 87), whereas the NFAT γ2 motif is nested ...

2014年7月8日 · NFAT’s regulatory domain can remain bound to the phosphatase by its LxVP motif. Our findings show that the LxVP-derived peptide binds to a site overlapped with the PxIxIT epitope, which resolves previous observations and establishes a distinct single Cn epitope as the key target for inhibiting the Cn/NFAT interaction.

2010年1月1日 · This chapter sheds light on the structure, regulation, and biological functions of the NFAT family, which is a family of transcription factors. The primordial NFAT family member NFAT5/TonEBP is expressed ubiquitously in mammalian cells and regulates the response to hypertonic stress.