活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类 转录因子 家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快速诱导其表达的转录因子而被发现。 NFAT在多种动物组织和细胞中广泛表达，是细胞内多条 信号转导通路 的关键调节点，在免疫系统、神经系统发育、轴突生长以及神经系统疾病中也发挥着重要作用。 NFAT蛋白的基本结构.

The NFAT transcription factor family consists of five members: NFATc1, NFATc2, NFATc3, NFATc4, and NFAT5. [2] . NFATc1 through NFATc4 are regulated by calcium signalling, and are known as the classical members of the NFAT family.

2005年6月1日 · The NFAT family consists of five members: NFAT1 (also known as NFATp or NFATc2), NFAT2 (also known as NFATc or NFATc1), NFAT3 (also known as NFATc4), NFAT4 (also known as NFATx or NFATc3) and...

2023年10月1日 · Here, we summarized the regulatory role of NFAT3 in the pathogenesis of cardiac hypertrophy from three aspects: i, the regulation of NFAT3 expression; ii, the regulation of NFAT3 localization; and iii, the regulation of NFAT3 transcript activity.

2024年12月25日 · NFATC3 (Nuclear Factor Of Activated T Cells 3) is a Protein Coding gene. Diseases associated with NFATC3 include Leukostasis and Polycystic Kidney Disease 3. Among its related pathways are Activation of cAMP-Dependent PKA and TCR Signaling (Qiagen).

NFAT3 (23E6) Rabbit mAb detects endogenous levels of total NFAT3 protein. Human, Mouse, Rat. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro143 of human NFAT3.

2010年8月20日 · NFAT proteins are of key importance for the induction of anergy-inducing genes such as gene related to anergy in lymphocytes (GRAIL), itchy homolog E3 ubiquitin protein ligase (ITCH), Casitas...

2024年6月27日 · 研究发现，长期注射锂的小鼠脑部GSK-3活性被抑制，神经元细胞发生NFAT3/4的核转位，从而诱导死亡配体（Fas Ligand，FasL）表达水平的上升，激活FasL/Fas凋亡通路，下游凋亡蛋白酶caspase-3表达增加，从而诱导随后的神经元凋亡。 基于当前环孢菌素A（Cyclosporin A）等药物在神经系统应用的局限性，例如，在体外培养的皮层神经元中，脑源性神经营养因子BDNF可以刺激NFAT依赖的转录，而使用CsA和FK506可以阻断该过程；传入神 …

2024年8月28日 · 活化的T细胞核内因子（NFAT）是免疫系统的关键转录因子，其家族成员广泛分布于多种动物组织和细胞中。 NFAT家族包含5个成员，各具独特表达特征，NFAT1、NFAT3在免疫系统中广泛表达，NFAT2在心血管和消化系统中含量较多，NFAT4存在于骨骼肌和平滑肌、肺等区域，NFAT5则是唯一已知的高渗透压激活的哺乳动物转录因子。 NFAT家族成员具有高度保守的结构域，包括NFAT同源区（NHR）和Rel同源结构域（RHD）。 NHR与NFAT的转录调节有 …

2 天之前 · Additionally, NFAT3 is known to be triggered by the pro-inflammatory cytokines and vice versa in several conditions, including in primary rat cortical neurons subjected to ischemic injury by transient oxygen-glucose deprivation, in toll-like receptor associated immune response in bone marrow-derived macrophages, in tumor promotion by cell ...