Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene. [5][6] The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex.

2024年12月25日 · NFATC3 (Nuclear Factor Of Activated T Cells 3) is a Protein Coding gene. Diseases associated with NFATC3 include Leukostasis and Polycystic Kidney Disease 3. Among its related pathways are Activation of cAMP-Dependent PKA and TCR Signaling (Qiagen).

2011年7月21日 · NFATc3 knock-down blocks IL2 and COX2 gene expression in human T cells and prevents their activation, whereas NFATc1 knock-down up-regulates the expression of IL2 and several other inflammatory modulators.

2019年6月27日 · Implanting U251 in an orthotopic intracranial assay, we show that specific NFATc3 silencing has a role in tumour growth. In addition NFATc3 knock-down affects both the proliferation and...

NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. data indicated that NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.

2021年9月27日 · Here, we show that NFATc3 levels in circulating peripheral blood mononuclear cells are negatively associated with disease severity in patients with atherosclerosis. Macrophage-specific knockout of NFATc3 promotes foam cell formation and …

2021年12月14日 · Macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating that the NFATc3/miR-204 axis may be a potential therapeutic target against atherosclerosis.

2025年2月8日 · Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms. Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition.

2011年7月21日 · Using mRNA knock-down, we show that NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in transformed and primary T cells and for T-cell proliferation. We also show that NFATc3 regulates COX2 in endothelial cells, where it is required for COX2, dependent migration and angiogenesis in vivo.

1995年8月25日 · NFATc3 activates NFAT site-dependent transcription when overexpressed, yet exhibits a pattern of DNA site specificity distinct from other NFATc proteins.