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In this review, we summarize the studies to-date on the NFX1 gene and its proteins across species and in humans, describing their role in gene regulation, embryonic development, cellular growth and differentiation, exogenous stress tolerance and metabolism, and an organism’s immune response.

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2023年10月11日 · We show that NFX-179 gel can penetrate human skin and inhibit MEK in both skin and cSCC explants. NFX-179 gel suppresses the development of SCCs in mice with minimal systemic side effects and reduces the viability of human cSCC cell lines.

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In a mouse model of NF1, mice given MEK inhibitors for two months showed significant decreases in neurofibroma tumor volume. Additionally, an oral MEK inhibitor is approved for the treatment of plexiform neurofibromas in NF1 patients.

A ready-to-use mix for SYBR Green qPCR, containing ROX reference and suitable for all qPCR instruments without adjusting the concentration of ROX. 1 vial of lyophilized qSTAR qPCR …

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