ECBs are actively produced in the neurogenic niche of the developing cortex and engage CB 1 receptors on NPs of the ventricular zone (VZ; figure 2), as identified by the expression of the neuroepithelial marker nestin and the transcription factor Sox2 [13,27].

2012年11月11日 · Here we show that the CB 1 receptor, by preventing Satb2 (special AT-rich binding protein 2)-mediated repression, increased Ctip2 (COUP-TF interacting protein 2) promoter activity, and Ctip2-positive neuron generation.

Here we show that the CB 1 receptor, by preventing Satb2 (special AT-rich binding protein 2)-mediated repression, increased Ctip2 (COUP-TF interacting protein 2) promoter activity, and Ctip2-positive neuron generation.

生殖干细胞 不对称分裂 产生的一个子细胞保留干细胞命运, 另一个子细胞则远离微环境形成包囊母细胞(cystoblast, CB)。位于果蝇卵巢的内原卵区鞘细胞（inner germarial sheath cells, IGS; 也被称为护卫细胞，escort cells）能够形成分化微环境，控制生殖干细胞子细胞的分化 ...

2020年11月3日 · Herein, we review the main properties of the different cell types in the CB germinal niche. We also summarize experimental data suggesting that O 2-sensitive glomus cells are the master regulators of CB plasticity. Upon exposure to hypoxia, neurotransmitters and neuromodulators released by glomus cells act as paracrine signals that induce ...

2005年1月26日 · We propose a unifying model to explain the gene circuitry of GSC and CB fate within the GSC niche. Our results suggest that Drosophila ovarian GSCs are retained as stem cells because Pum:Nos complexes repress translation of a pool of mRNAs that induce CB differentiation (Figure 4).

2012年12月5日 · A number of recent studies have revealed a previously unknown role for the endocannabinoid (ECB) system in the control of embryonic neuronal development and maturation. Thus, the CB(1) cannabinoid receptor in concert with locally produced ECBs regulates neural progenitor (NP) proliferation, pyramidal specification and axonal navigation.

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2024年4月1日 · Single cell RNA-seq analysis was performed on sorted population of CD45+/CD34+ HSPCs from cord blood (CB) and mobilized peripheral blood (mPB) donors, after co-culture with vascular niche cells, to uncover differential transcriptional output between HSPC derived from CB and mPB origins.

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