2024年12月5日 · Our finding of SYR and its glycoside derivatives, as a structural subfamily of lignan compounds that exert an antidepressant activity by targeting the S2 site in SERT, opens the possibility of developing novel antidepressant agents based on SYR as a lead compound.

2021年12月15日 · We found that SYR protected cardiomyocytes from sepsis-induced injury in a SIRT1-dependent way, inhibition of SIRT1 abolished SYR's regulation on NLRP3, and thus the protective effect of SYR on myocardial cells was eliminated.

2024年10月10日 · Our work describes the engineering of a designed NRPS/PKS hybrid via the assembly of different megasynthetase fragments to produce a rationally modified syrbactin derivative with a complex peptide-polyketide structure, acting as proteasome inhibitor.

The present study aimed to investigate the pharmacodynamic effect of SYR on diabetic cardiomyopathy and the underlying molecular mechanism. Methods and results: In STZ-induced type 1 diabetic mice, orally administration with SYR in every other day for 8 weeks significantly improves cardiac dysfunction and preventes cardiac hypertrophy and fibrosis.

Syringaresinol (SYR) possesses anti-inflammatory and antioxidant properties. However, the therapeutic effects and the underlying mechanism of SYR in DN remain unclear. Herein, we showed that SYR treatment ameliorated renal hypertrophy, fibrosis, mesangial expansion, glomerular basement membrane thickening, and podocyte foot process effacement ...

2000年12月1日 · Syntaxins and other SNARE proteins are crucial for intracellular vesicle trafficking, fusion and secretion. Previously, we isolated the syntaxin-related protein Nt-Syr1 from Nicotiana in a screen...

2025年2月24日 · To understand the transcriptional mechanism through which SYR1 and SYR2 are differentially regulated by MYC2-dependent JA signaling, we examined the SYR promoters for putative MYC2 binding motifs and identified a G-box-like motif (5′-CACGTT-3′) in SYR2 promoter and two G-box-like variants (5′-CACTTG-3′) in SYR1 promoter (Figure 7 E).

2015年12月2日 · Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

2018年2月19日 · SYR1 acts as a genuine systemin receptor that binds systemin with high affinity and specificity. Further, we show that presence of SYR1, although not decisive for local and systemic wound...

To address this need, this thesis investigates the effectiveness of a benchtop nitric oxide (NOx) sterilization process and the extent to which the process affects the shape memory behavior of a well-studied tert-Butyl Acrylate (tBA) SMP. Quantifying the effects on shape memory behavior was performed using a two-tiered analysis.