Natural killer cells, also known as NK cells, are a type of cytotoxic lymphocyte critical to the innate immune system. They are a kind of large granular lymphocytes [1] [2] (LGL), and belong to the rapidly expanding family of known innate lymphoid cells (ILC) and represent 5–20% of all circulating lymphocytes in humans. [3]

2023年4月10日 · Natural killer cells (NK cells) are white blood cells that destroy infected cells and cancer cells in your body. NK cells are important fighters in your immune system. Your immune system protects you from harmful invaders, like pathogens …

Natural killer (NK) cells are a type of cytotoxic lymphocyte critical to the innate immune system. They provide rapid responses to viral-infected cells and tumor formation, acting at around 3 days after infection.

2024年11月8日 · Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell killing and tumor destruction, are pivotal in immunity. They exhibit multifaceted roles in...

In this review, we provide a general overview of human NK cells, as opposed to murine NK cells, discussing their ontogeny, maturation, receptor diversity, types of responses, and effector functions.

2008年8月1日 · Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration.

A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells.

2022年4月28日 · Natural killer (NK) cells are a group of innate lymphocyte cells with cytolytic activity against virus-infected cells and physiologically stressed cells like tumor cells. Initially, NK cells were described as larger granular lymphocytes with cytotoxic activity against tumor cells.

2022年4月22日 · Natural killer (NK) cells are commonly described as being “innate immune effector cells that can lyse virally infected and tumorigenic cells without prior antigen sensitization.” 1-3 This fundamental description arises from the properties first attributed to NK cells following their discovery almost 50 years ago.

2025年1月9日 · Natural killer (NK) cells are integral to the body’s immune surveillance system, constantly patrolling for signs of infection or cellular abnormalities. Their primary function is to monitor and eliminate cells that exhibit signs of stress or transformation, such as tumor cells or those infected by viruses.