CD16 - Wikipedia
CD16 plays a significant role in early activation of natural killer (NK) cells following vaccination. In addition, CD16 downregulation represents a possible way to moderate NK cell responses and …
NK cell CD16 surface expression and function is regulated by a ...
Activated NK cells loose CD16 (FcRγIII) and CD62L through a metalloprotease called ADAM17. Inhibition of ADAM17 enhances CD16 mediated NK cell function by preserving CD16 on the …
NK细胞：抗肿瘤第一道防线|NK细胞|CD16|肿瘤|抗体|免疫|-健康界
2023年2月13日 · nk细胞可通过cd16受体介导的adcc，杀死igg1或igg3抗体靶向的细胞。nk细胞表面cd16的不同形态，会影响cd16与抗体fc端的亲和力。 具体来说，cd16蛋白第158位的氨基 …
NK cell CD16 surface expression and function is regulated by a ... - PubMed
2013年5月2日 · The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to …
Distinct CD16a features on human NK cells observed by flow …
2024年4月4日 · Improving the NK cell response, either through enhancing NK cell responses or identifying features of NK cells with superior cytotoxic potential, is widely expected to improve …
Comparison of the different anti-CD16 antibody clones in the
2023年6月11日 · CD16 (Fcγ receptor III) is a receptor expressed on NK cells that facilitates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various …
CD16 is indispensable for antibody-dependent cellular ... - Nature
2016年9月27日 · CD16, the FcγRIIIA, is essential for ADCC by NK cells, and is also expressed by a subset of human blood monocytes. We found that human CD16− expressing monocytes …
既可甄别NK细胞又能激发ADCC反应的靶向分子的CD16介绍
2022年9月26日 · 根据CD16、CD56表达的差异，可以将NK细胞分为两大亚型：CD56 dim CD16 + NK和CD56 bright CD16-NK。 CD56 bright NK - 细胞是强有力的细胞因子产生者，但缺 …
CAR-NK细胞疗法克服髓系恶性肿瘤治疗的障碍与挑战
2025年3月8日 · Zhang等通过增强CD16信号通路，使CAR-NK细胞同时靶向CD33和B16，提高了细胞毒性四倍，同时保持良好的安全性。 CD123 Morgan等通过基因工程改造NK细胞，使其 …
Harnessing CD16-Mediated NK Cell Functions to Enhance
2021年5月20日 · Natural killer (NK) cells hold a pivotal role in tumor-targeting monoclonal antibody (mAb)-based activity due to the expression of CD16, the low-affinity receptor for IgG. …