2021年12月20日 · 自然杀伤 (Natural Killer, NK)细胞受体家族2 (NKG2)包括NKG2A/B/C/D/E/F。其中NKG2A是NKG2受体家族中抑制性的受体, 也被称为自然杀伤细胞凝集素样受体C1 (killer cell lectin like receptor C1, KLRC1), CD159a、NK细胞受体A，是NK细胞表面优先表达的跨膜蛋白之一。

2023年10月18日 · 自然杀伤（nk）细胞作为肿瘤微环境（tme）的重要组成部分之一，参与了多种抗肿瘤过程，如直接杀伤肿瘤细胞和分泌促炎细胞因子。利用 nk 细胞治疗癌症的策略层出不穷，其特点是安全性和有效性都很好。

李焱等对 急性髓系白血病 患者骨髓来源CD34+白血病细胞进行体外诱导分化实验，CD34+白血病细胞可在体外诱导分化为NK细胞，且具有杀伤活性。 联合应用IL-12、1L-15细胞因子组合能够诱导分化的NK细胞活性，提高对白血病细胞的杀伤率以及TNF-α和IFN-γ等基因表达水平。 图片来源：李焱 等.临床肿瘤学杂志,2019. 3、增强NK细胞毒性作用：IL-12/18/21. Guia S等研究发现在IL12RB1突变导致IL-12Rbeta1完全缺乏的患者中，NK细胞亚群明显减少，特别是对于IFN-γ …

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In this review, we provide a general overview of human NK cells, as opposed to murine NK cells, discussing their ontogeny, maturation, receptor diversity, types of responses, and effector functions.

2020年2月13日 · Integrating high-dimensional analysis of NK cells from blood, lymphoid organs, and mucosal tissue sites from 60 individuals, we identify tissue-specific patterns of NK cell subset distribution, maturation, and function maintained across age and between individuals.

The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated 'senescent' cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK c …

2014年10月1日 · Background: Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has been associated with ...

2021年3月12日 · Natural killer (NK) cells, which are key components of the innate immune system, have been implicated in the development of multiple autoimmune diseases such as systemic lupus erythematosus, type I diabetes mellitus, and autoimmune liver disease.

BACKGROUND: The aim of these clinical standards is to aid the diagnosis and management of asthma in low-resource settings in low- and middle-income countries (LMICs). METHODS: A …