NKX3-1 is an androgen-regulated, prostate-specific homeobox gene whose expression is predominantly localized to prostate epithelium. It acts as a transcription factor that has critical function in prostate development and tumor suppression.

2021年2月24日 · NKX3.1 gene encodes a transcription factor of the homeobox family During prostate development, NKX3.1 is expressed in an androgen dependent manner and regulates the formation of prostatic epithelium and ducts (Int J Stem Cells 2021;14:168)

NKX3.1 seems to be a highly sensitive and specific tissue marker of metastatic prostatic adenocarcinoma. In the appropriate clinical setting, the addition of IHC staining for NKX3.1, along with other prostate-restricted markers, may prove to be a valuable adjunct to definitively determine prostatic origin in poorly differentiated metastatic ...

NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p. Although most studies have shown that staining for NKX3.1 protein is positive in the majority of primary prostatic adenocarcinomas, it has been shown to be downregulated in many ...

2024年12月25日 · NKX3-1 (NK3 Homeobox 1) is a Protein Coding gene. Diseases associated with NKX3-1 include Prostate Cancer and Cervical Adenoid Basal Carcinoma. Among its related pathways are FOXA1 transcription factor network and Sudden infant death syndrome (SIDS) susceptibility pathways.

nkx3.1是一个生长抑制子，能够调节细胞凋亡、诱导抗氧化物产生和dna修复的加强。pten是一个广泛存在的肿瘤抑制因子，在前列腺癌肿瘤恶化期间表达减少。nkx3.1的稳态转变由dyrk1b磷酸化nkx3.1蛋白第185个氨基酸-丝氨酸调控，且能够导致多聚泛素化和蛋白酶体降解。

摘要 目的:同源框基因nkx3.1与前列腺癌发生和进展关系密切,本研究探索前列腺癌中nkx3.1调控的相关下游节点基因及可能的调控机制。方法:首先对前列腺癌相关的公开数据库进行生物信息多组学数据分析,筛选出与nkx3.1可能相...

NKX3.1 is an emerging marker for tumors of prostatic origin; however, the utility and diagnostic values of NKX3.1 have not been broadly studied in cytology specimens. The purpose of this study is to determine the performance of NKX3.1, compared to ...

NKX3.1阳性是前列腺癌筛查中的一个重要指标，高度关联于前列腺癌的诊断。 当你听到“NKX3.1阳性”这个词时，是否会感到困惑和不安？ 其实，NKX3.1是一种基因标记，它在前列腺癌的研究中扮演着重要角色。 那么，nkx3.1阳性到底意味着什么呢？ 接下来，我们就来详细了解一下。 NKX3.1阳性的病因主要与前列腺的生理过程、上皮分化和肿瘤发生发展密切相关。 在前列腺癌中，NKX3.1的表达水平通常会有所变化，成为其诊断的特异性标志物之一。 此外，NKX3.1 …

2025年1月18日 · Our results indicate that NKX3.1 is a critical co-factor for AR in prostate cancer cells, and knockdown leads to decreased cell survival, while overexpression is enough to promote growth in androgen depleted and AR-inhibited conditions.