2024年12月25日 · NLRP6 (NLR Family Pyrin Domain Containing 6) is a Protein Coding gene. Diseases associated with NLRP6 include Colitis and Chemical Colitis. Gene Ontology (GO) annotations related to this gene include vasopressin receptor activity. An important paralog of …

为了进一步检测小鼠体内凝聚体的形成，通过免疫荧光实验发现在野生型小鼠的肝脏切片中出现了dsrna与nlrp6以及asc与nlrp6形成的凝聚体，而该凝聚体在nlrp6敲除小鼠无法形成，说明mhv感染的确可以诱导nlrp6凝聚体的形成。

2021年4月27日 · NLRP6 exhibits diverse functions in the regulation of host response against pathogenic infections and gut inflammation. Emerging evidence suggests context-reliant inflammasome-dependent and -independent functions.

2021年11月11日 · NLRP6 is important in host defense by inducing functional outcomes including inflammasome activation and interferon production. Here, we show that NLRP6 undergoes liquid-liquid phase separation (LLPS) upon interaction with double-stranded RNA (dsRNA) in vitro and in cells, and an intrinsically disor …

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors .

2020年1月27日 · NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is a member of the NLR (nucleotide-oligomerization domain-like receptor) family that patrols the cytosolic...

近期，来自中国科学技术大学的朱书在 《Molecular Aspects of Medicine》上发表的一篇综述文章 NLRP6 inflammasome ，详细介绍了NLRP6炎性小体活化的调控机制、NLRP6在肠道细胞及免疫细胞中发挥的功能、NLRP6与NLRP9如何协作调节肠道抗病毒免疫应答，以及靶向NLRP6治疗疾 …

2022年4月2日 · 本课题组最新研究发现，在肺炎链球菌(Streptococcus pneumoniae)分别感染NLRP6 –/– 、WT小鼠的腹腔巨噬细胞时，NLRP6敲除组中的p-p65、p-ERK1/2和p-IκBα表达水平明显升高 ，表明NLRP6负调节炎症性NF-κB和ERK信号通路。NLRP6缺失时，NLRP3激活可能作为一种补偿机制，两种炎症 ...

NOD-like receptor family pyrin domain containing 6 (NLRP6) is a novel NLR family member, that shows high expression in the intestine and liver (in contrast to NLRP3 in myeloid cells), to regulate inflammation and host defense against microbes.

NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other NLRs, NLRP6 not only participates in inflammasome formation, but is also involved in nuclear factor-κ …