2012年4月1日 · Three lines of evidence demonstrate the anti-metastatic activity of NM23: first, overexpression of NM23 in metastatic cell lines reduces their metastatic potential in xenograft models; second, the incidence of lung metastases is elevated in NM23 knockout mice prone to develop hepatocellular carcinoma, and, third, silencing NM23 by RNA ...

Metastasis suppressor genes (MSGs) inhibit different biological processes during metastatic progression without globally influencing development of the primary tumor. The first MSG, NM23 (non-metastatic clone 23, isoform H1) or now called NME1 ...

Group I NM23 genes encode enzymes with evolutionarily highly conserved nucleoside diphosphate kinase (NDPK) activity. In this review we summarize how results from NDPKs in model organisms converged on human NM23 studies.

2021年3月22日 · Non-metastatic protein 23 H1 (Nm23-H1), a housekeeping enzyme, is a nucleoside diphosphate kinase-A (NDPK-A). It was the first identified metastasis suppressor protein.

In this light, further understanding of Lamins/TRF1/2/NM23-H2 or FEN1/NM23-H2 associations might provide meaningful insights into the role of NM23 proteins in telomere biology. Finally, multiple pieces of evidence of the mitochondrial NM23 protein suggests an …

2021年3月1日 · This review summarized and discussed the regulatory mechanisms of NM23-H1 in cancer including transcriptional activation, subcellular location, enzymatic activity, and protein degradation, which significantly modulate its anti-metastatic function.

2020年3月18日 · The metastasis suppressor gene NME/nm23/NDPK was discovered in 1988 by Steeg et al, 1 from the analysis of murine melanoma K-1735 cells based on its differential expression with respect to metastatic potential. The first identified member of the nm23 metastasis suppressor gene

NM23 is the first discovered metastasis suppressor gene, which does not affect the growth of primary tumor but a powerful inhibitor of metastases of tumors. Altered NM23 expression was found to be closely related to various tumor metastases, including NSCLC.

2006年6月1日 · The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas.

2017年1月1日 · The nm23 gene was discovered using differential colony hybridization between low and high tumor metastatic potential K-1735 murine melanoma cell lines. Nm23 mRNA and protein levels were quantitatively higher in two cell lines of low metastatic potential than five related, more highly metastatic cell lines.