Neuromuscular blocking agents are potent muscle relaxants typically only used during surgery to prevent muscle movement. They are structurally related to acetylcholine (the main neurotransmitter in the body) and they cause muscle relaxation by binding to acetylcholine receptors postsynaptically (which prevents acetylcholine from binding).

Neuromuscular-blocking drugs, or Neuromuscular blocking agents (NMBAs), block transmission at the neuromuscular junction, [1] causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors.

2024年6月8日 · The widespread adoption of neuromuscular blocking agents (NMBAs), or drugs (NMBDs), significantly impacted the field of anesthesia. Before the introduction of NMBAs, anesthesia was induced and maintained with intravenous and inhalational agents.

2024年6月14日 · Although a startling concept, the neuromuscular blocking agent (NMBA) drug class is used to induce complete muscle paralysis within seconds to minutes. The purpose of these drugs in operating rooms, intensive care units (ICU), and emergency rooms is to facilitate the placement of a breathing tube, the use of a ventilator, or surgery.

2023年11月13日 · Neuromuscular blockade is frequently used in anesthesia to facilitate endotracheal intubation, optimize surgical conditions, and assist with mechanical ventilation in patients with reduced lung compliance.

2017年1月19日 · Neuromuscular blocking agents (NMBAs) play an important role in the management of a large number of hospital patients. In addition to their routine use in surgical anesthesia, NMBAs may be valuable in many new and evolving critical care situations.

神经肌肉阻断药 (neuromuscular blocking agent, NMBA)可阻断神经肌接头处的神经冲动传导，从而使骨骼肌松弛。 NMBA可用于ICU中的数种适应证。 本专题将讨论NMBA在危重患者中的临床应用、给药和潜在不良反应。 NMBA的药理学、在麻醉患者中的应用和急诊科插管中的应用详见其他专题。 (参见 “神经肌肉阻滞剂在麻醉中的临床应用” 和 “急诊和重症医疗中神经肌肉阻断剂用于成人快速诱导插管”) NMBA (表 1)可阻断乙酰胆碱 (acetylcholine, ACh)与运动终板结合。 根据作用 …

2025年2月4日 · Neuromuscular blocking agents (NMBAs) are a class of drugs that prevent nerve impulses from reaching muscles, effectively causing temporary paralysis of the skeletal muscles. These agents are commonly used during surgeries and in critical care settings to facilitate intubation and mechanical ventilation , ensure muscle relaxation, and improve ...

Neuromuscular blocking agents (NMBA) are drugs that affect the motor endplate of striated muscles 1 by blocking the transmission of nerve impulses at the neuromuscular junction.

Neuromuscular blocking agents (NMBAs) are used to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. NMBAs cause respiratory paralysis; persons must be intubated when receiving an NMBA.