2024年12月25日 · NMD3 (NMD3 Ribosome Export Adaptor) is a Protein Coding gene. Diseases associated with NMD3 include Palmoplantar Keratoderma, Bothnian Type and Shwachman-Diamond Syndrome 1. Gene Ontology (GO) annotations related to this gene include RNA binding and ribosomal large subunit binding.

60S ribosomal export protein NMD3 is a protein that in humans is encoded by the NMD3 gene. [5] [6] [7]

2020年7月15日 · Here we present four structures of human pre-60S particles isolated through a nuclear export factor NMD3, representing assembly stages immediately before and after nuclear export. These...

研究者利用化学蛋白质组学阐明了PA的细胞靶点，揭示PA能够靶向核糖体60S亚基输出蛋白 NMD3，阻断多聚体形成并抑制蛋白质翻译，发挥强大的抗肿瘤作用。 受萜类化合物的两相合成途径（two-phase strategy）启发，研究者以portimines的最小氧化大环中间体为目标，调整了合成氧化顺序。 利用C-7/C-8上的炔基替代最终的C-7氧化，通过炔烃环合复分解反应（RCAM），最大限度地减少不稳定的官能团和后续（C-5、C-13、C-14和C-15）的氧化还原操作。 反推在解开 …

nmd3 核糖体输出适配器： 核糖体 40s 和 60s 亚基结合在核仁中并输出到细胞质。 该基因编码的蛋白质参与 60S 亚基通过核孔复合体进入细胞质的过程。 该基因存在多个转录本变体，但迄今为止仅描述了其中两个的全长性质。

2023年9月20日 · NMD3 is an adaptor of 60S ribosomal subunit nuclear export and is released after pre-60S maturation and subsequent polysome formation, though the precise mechanism of this process is not fully ...

2017年1月23日 · Nmd3, a highly conserved protein in eukaryotes, is a specific adaptor required for the export of pre-60S particles. Here we used cryo-electron microscopy (cryo-EM) to characterize Saccharomyces...

2025年2月8日 · Gene ID: 51068, updated on 8-Feb-2025. Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the …

A mutation in NMD3 was found to be lethal in the absence of XRN1, which encodes the major cytoplasmic exoribonuclease responsible for mRNA turnover. Molecular genetic analysis of NMD3 revealed that it is an essential gene required for stable 60S ...

2023年10月23日 · 化学蛋白质组学实验进一步确定 portinine A的主要靶点是60S核糖体输出蛋白NMD3。 几十年以来，环亚胺毒素引起了科学界的广泛兴趣，其具有独特的化学结构和强效生物活性。 该类化合物中的部分化合物的治疗潜力，例如pinnatoxins、spirolides、gymnodimines类，因具有体内高神经毒性而受到限制。 Portinine A (PA, 1)和Portinine B (PB, 2) 是在2013年和2018年从底栖甲藻Vulcanodinium rugosum中分离得出的两个更紧凑环亚胺毒素（Fig. 1, 绝对构型 …