2014年4月1日 · The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative levels of physical activity are the major determinants...

To further assess NMJ maturation in CP and IS patients, we performed an additional phase of studies utilizing transmission electron microscopy (TEM) to examine the number and length of ...

这 果蝇 幼虫神经肌肉接头（NMJ）是众所周知的模型系统，经常用于研究突触发育。 在这里，我们主要基于透射电子显微镜 (TEM) 研究，展示了 NMJ 突触变性。 当退化开始时，突触下网（SSR）膨胀、收缩并向内折叠，残余的 SSR 然后退化成无序的、薄的或线性的膜。 轴突末梢从中心区域开始退化，T形杆与突触前膜脱离，突触小泡聚集，加速大规模退化。 透明突触小泡有两种变性模式。 在第一种模式中，没有肌动蛋白丝的突触小泡在膜上退化，具有超细斑点，并 …

2023年12月19日 · Here, we report the development of a robust and efficient self-organizing neuromuscular junction (soNMJ) model from human pluripotent stem cells that can be maintained long-term in simple adherent...

Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies. When degeneration starts, the subsynaptic reticulum (SSR) swells, retracts and folds inward, and the residual SSR then degenerates into a …

2023年11月1日 · The Drosophila larval neuromuscular junction (NMJ) is a well-known model system and is often used to study synapse development. Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies.

2010年6月25日 · Reliable means to locate NMJs for ultrastructural analysis using straightforward methodology would greatly improve the utility of TEM in research and clinical diagnostics of NMJ-associated diseases. Therefore, we have a developed a simple correlative method that allows NMJs to be first screened, identified and mapped by conventional ...

2022年4月25日 · Maintenance of the NMJ relies upon neural agrin (n-agrin) which, when released from the nerve terminal, activates the postsynaptic Muscle Specific Kinase (MuSK) signaling complex to stabilize clusters of acetylcholine receptors. Here, we report that muscle from MND patients has an increased proportion of slow fibers and muscle fibers with ...

2010年8月30日 · The physiological processes regulating neuromuscular transmission are highly dependent on the structural features of the motor neuron and motor endplate, and detailing the structure of neuromuscular junctions (NMJs) in muscle biopsies is a powerful method for research and diagnostics.

2008年1月1日 · The neuromuscular junction (NMJ) is a chemical synapse that is anatomically and functionally differentiated for the transmission of a signal from the motor nerve terminal to a circumscribed postsynaptic region on the muscle fiber.