Knowing the signs of low IGF-1 levels in adults early is crucial. It helps in starting health treatments soon. This greatly helps those dealing with adult growth hormone deficiency. This article looks at the many common adult growth hormone deficiency symptoms closely. It shows how knowing about them and acting early are very important.

2025年2月10日 · Receptors of insulin and insulin-like growth factors (IGFs) are receptor tyrosine kinases whose signalling controls multiple aspects of animal physiology throughout life. In...

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. [5] .

2021年10月1日 · The IGF-II receptor (cation-independent mannose-6-phosphate receptor, M6P/IGF-IIR) is a single-chain transmembrane protein that binds IGF-II and mannose-6-phosphate-containing proteins. Unlike the IR and IGF-IR, the M6P/IGF-IIR has no catalytic function and therefore does not activate intracellular signaling processes.

2019年12月1日 · Most studies show no increase in circulating total insulin-like growth factor (IGF)-1, whereas bioactivity of IGF-1 may change in response to exercise. GH deficiency presents with low muscle mass and impaired exercise capacity that …

Insulin-like growth factor I (IGF-I) is a potent hormone that stimulates growth and differentiation and inhibits apoptosis in numerous tissues. Preliminary evidence suggests that IGF-I exerts differentiating, mitogenic and restoring activities in the immune system but the sites of synthesis of local IGF-I are unknown.

2016年1月6日 · In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients.

There are eight known genetic causes of short stature characterized by low serum IGF-1 (IGF-1 deficiency, IGFD) and normal GH secretion. One of these (GHSR defect) is a form of secondary IGFD, although the GH peak in provocation tests can be normal.

本研究通过大鼠颅骨成骨细胞实验，探讨IGF-1R/NO信号通路在PEMF促进成骨细胞成熟和矿化过程中的可能作用。 SPF级SD大鼠由甘肃中医药大学动物实验中心提供 [SCXK (甘)2015-0002]。 实验符合中国人民解放军联勤保障部队第九四〇医院关于动物实验的伦理规定。

摘要： 胰岛素样生长因子（insulin-like growth factors，IGFs）是一个多功能的生长因子家族，对细胞的生长、分化和凋亡起着重要的调节作用。 概述近年来在IGFs的成分、结构功能、信号通路以及在疾病中的作用等方面的研究进展，以期为细胞生长调控、动物胚胎发育及肿瘤发生等方面的研究提供参考。 Abstract: Insulin-like growth factors（IGFs）is a multifunctional growth factor family, and plays an important role in cell growth, differentiation and apoptosis.