转铁蛋白受体 TFR1是介导铁离子进入细胞通道的关键成员之一，在调节细胞铁代谢和维持铁平衡中发挥关键作用。 细胞铁缺乏可以抑制细胞生长，从而导致细胞死亡。

Transferrin receptor protein 1 (TfR1), also known as C luster of D ifferentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [5][6] TfR1 is required for iron import from transferrin into cells by endocytosis. [7][8] TfR1 = transferrin receptor 1 in Human iron metabolism.

2024年10月23日 · 转铁蛋白受体TFR1是介导铁离子进入细胞通道的关键成员之一，在调节细胞铁代谢和维持铁平衡中发挥关键作用。 癌细胞为了快速增殖需要大量铁，导致细胞表面转铁蛋白受体1（TfR1）显著上调，TfR1通过与携铁蛋白转铁蛋白结合来介导铁的摄取。

转铁蛋白受体1 （transferrin protein, TFR1），也被称为 CD71 或 TFRC，是一种90kDa的II型跨膜糖蛋白，由760个氨基酸组成，以二聚体的形式存在，通过细胞表面的二硫键连接。 TFR1单体由胞外C末端结构域、跨膜区和细胞内N末端结构域组成，其中C端区域包含了转铁蛋白 （transferrin，TF） 的结合位点。 每个TFR1单体可结合1分子TF和2个Fe3+，那么1分子TFR1最多可结合2分子TF和4个Fe3+，最终以铁-TF-TFR1复合物形式将铁运送至细胞内。 图1. TFR1 …

2024年9月25日 · To develop a new method for high-efficacy degradation of membrane proteins applicable across a wide scope of tissue types, we identified transferrin receptor 1 (TfR1) as a promising cellular...

2021年3月17日 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf. Iron is required for multiple cellular processes …

2025年3月13日 · Nanobodies targeting TfR1 hold great potential for interfering with tumor iron uptake and inhibiting cancer cell growth. However, the efficient screening of anti-TfR1 nanobodies with high affinity and specificity remains a significant challenge. This study presents a simplified method for the rapid screening and validation of anti-TfR1 nanobodies.

2025年3月30日 · TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include Immunodeficiency 46 and Combined Immunodeficiency. Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle. Gene Ontology (GO) annotations related to this gene include RNA binding and double-stranded RNA binding.

2024年2月1日 · Given the important role of the transferrin receptor 1 (TfR1) in regulating iron distribution in the brain, as well as in the drug delivery, we investigated its expression in the brain cortex and isolated brain microvessels from female 8 …

2017年3月25日 · HTLV-1-associated adult T-cell leukemia/lymphoma (ATLL) has no effective therapy and high levels of cell surface transferrin receptor 1 (TFR1) expression have been reported in ATLL by us and other groups.